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    GCV1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851582, updated on 11-Sep-2024

    Summary

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    Official Symbol
    GCV1
    Primary source
    SGD:S000002426
    Locus tag
    YDR019C
    See related
    AllianceGenome:SGD:S000002426; FungiDB:YDR019C; VEuPathDB:YDR019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GSD1
    Summary
    Contributes to glycine dehydrogenase (decarboxylating) activity. Involved in glycine metabolic process and one-carbon metabolic process. Located in mitochondrion. Part of glycine cleavage complex. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (484163..485365, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate kinase KCS1 Neighboring gene putative acyltransferase Neighboring gene putative uridine kinase DAS2 Neighboring gene ATP-dependent RNA helicase FAL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the yeast glycine cleavage genes is responsive to the availability of multiple nutrients. Piper MD, et al. FEMS Yeast Res, 2002 Mar. PMID 12702322
    2. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif. Hong SP, et al. J Biol Chem, 1999 Apr 9. PMID 10187845
    3. Genetics of the synthesis of serine from glycine and the utilization of glycine as sole nitrogen source by Saccharomyces cerevisiae. Sinclair DA, et al. Genetics, 1995 Aug. PMID 7498764, Free PMC Article
    4. Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae. Gelling CL, et al. J Biol Chem, 2004 Feb 20. PMID 14645232
    5. Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae. Piper MD, et al. J Biol Chem, 2000 Oct 6. PMID 10871621

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to glycine dehydrogenase (decarboxylating) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glycine cleavage complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycine cleavage complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycine decarboxylase subunit T
    NP_010302.1
    • T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      484163..485365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180327.1 → NP_010302.1  TPA: glycine decarboxylase subunit T [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010302.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS05, P48015
      UniProtKB/TrEMBL
      A6ZXY3, B3LGP5, B5VFS7, C7GLX7, C8Z4T9, N1P622
      Conserved Domains (1) summary
      TIGR00528
      Location:16 → 395
      gcvT; glycine cleavage system T protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48015.2

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