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    ILV1 threonine ammonia-lyase ILV1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856819, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ILV1
    Official Full Name
    threonine ammonia-lyase ILV1
    Primary source
    SGD:S000000888
    Locus tag
    YER086W
    See related
    AllianceGenome:SGD:S000000888; FungiDB:YER086W; VEuPathDB:YER086W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ISO1
    Summary
    Enables threonine deaminase activity. Involved in isoleucine biosynthetic process and threonine catabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ILV1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (328477..330207)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene putative proline--tRNA ligase AIM10 Neighboring gene Arf family guanine nucleotide exchange factor SBH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dominance and recessiveness at the protein level in mutant x wildtype crosses in Sacchaomyces cerevisiae. Zimmermann FK, et al. Mol Gen Genet, 1969 Aug 15. PMID 5367408
    2. Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae. Altered threonine deaminase in an is-1 mutant responding to threonine. Brunner A, et al. Eur J Biochem, 1969 Aug. PMID 5345980
    3. Purification and properties of threonine deaminase from Saccharomyces cerevisiae. Ahmed SI, et al. Biochimie, 1976. PMID 782558
    4. Threonine deaminases from Saccharomyces cerevisiae mutationally altered in regulatory properties. Betz JL, et al. Biochemistry, 1971 May 11. PMID 5563764
    5. Datin, a yeast poly(dA:dT)-binding protein, behaves as an activator of the wild-type ILV1 promoter and interacts synergistically with Reb1p. Moreira JM, et al. Mol Gen Genet, 1998 Apr. PMID 9613577

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Substitution of histone H3 arginine 72 to alanine leads to the deregulation of isoleucine biosynthesis in the budding yeast Saccharomyces cerevisiae.
      Title: Substitution of histone H3 arginine 72 to alanine leads to the deregulation of isoleucine biosynthesis in the budding yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-serine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoleucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in threonine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonine catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    threonine ammonia-lyase ILV1
    NP_011009.1
    • Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      328477..330207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178977.1 → NP_011009.1  TPA: threonine ammonia-lyase ILV1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011009.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLZ2, P00927
      UniProtKB/TrEMBL
      A6ZR41, B3LRK3, C7GRR8, C8Z799, G2WCX6, N1P3G3
      Conserved Domains (1) summary
      PRK09224
      Location:61 → 575
      PRK09224; threonine ammonia-lyase IlvA
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00927.2

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