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    sur2 sphingosine hydroxylase/sphingolipid delta-4 desaturase Sur2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541225, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sur2
    Official Full Name
    sphingosine hydroxylase/sphingolipid delta-4 desaturase Sur2
    Primary source
    PomBase:SPBC887.15c
    Locus tag
    SPOM_SPBC887.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sur2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3570849..3572596, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 3-oxoacyl-[acyl-carrier-protein]-synthase condensing enzyme Neighboring gene ncRNA Neighboring gene DNA repair and recombination protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of sur2 mutation affecting the lifespan of fission yeast. Kurauchi T, et al. FEMS Microbiol Lett, 2021 Jun 24. PMID 34114004
    2. Characterization of bifunctional sphingolipid Δ4-desaturases/C4-hydroxylases of trypanosomatids by liquid chromatography-electrospray tandem mass spectrometry. Vacchina P, et al. Mol Biochem Parasitol, 2012 Jul. PMID 22542487
    3. Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe. Nakase M, et al. J Cell Sci, 2010 May 1. PMID 20388730
    4. Systematic analysis reveals the prevalence and principles of bypassable gene essentiality. Li J, et al. Nat Commun, 2019 Mar 1. PMID 30824696, Free PMC Article
    5. High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library. Varberg JM, et al. G3 (Bethesda), 2020 Dec 3. PMID 33109728, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of sur2 mutation affecting the lifespan of fission yeast.
      Title: Identification of sur2 mutation affecting the lifespan of fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables iron ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables sphingolipid delta-4 desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingolipid delta-4 desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables sphingolipid delta-4 desaturase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sphingosine hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine hydroxylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables sphingosine hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mannosyl-inositol phosphorylceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannosyl-inositol phosphorylceramide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine hydroxylase/sphingolipid delta-4 desaturase Sur2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3570849..3572596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022409.3 → NP_596489.1  sphingosine hydroxylase/sphingolipid delta-4 desaturase Sur2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596489.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94298
      Conserved Domains (2) summary
      COG3000
      Location:7 → 279
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:135 → 270
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials