U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hrp1 CENP-A chaperone, CHD family Hrp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542363, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hrp1
    Official Full Name
    CENP-A chaperone, CHD family Hrp1
    Primary source
    PomBase:SPAC1783.05
    Locus tag
    SPOM_SPAC1783.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    chd1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See hrp1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2194821..2199471)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene CENP-P family protein Fta2 Neighboring gene ncRNA Neighboring gene histone deacetylase, Sirtuin family, NAD-dependent Hst4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene autophagy-associated ubiquitin-like modifier Atg12 Neighboring gene ncRNA Neighboring gene DNA-binding transcription factor, oxidative stress-responsive Pap1/Caf3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fission yeast hrp1, a chromodomain ATPase, is required for proper chromosome segregation and its overexpression interferes with chromatin condensation. Yoo EJ, et al. Nucleic Acids Res, 2000 May 1. PMID 10756203, Free PMC Article
    2. Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription. Hennig BP, et al. EMBO Rep, 2012 Nov 6. PMID 23032292, Free PMC Article
    3. CHD1 remodelers regulate nucleosome spacing in vitro and align nucleosomal arrays over gene coding regions in S. pombe. Pointner J, et al. EMBO J, 2012 Nov 28. PMID 23103765, Free PMC Article
    4. A genome-wide role for CHD remodelling factors and Nap1 in nucleosome disassembly. Walfridsson J, et al. EMBO J, 2007 Jun 20. PMID 17510629, Free PMC Article
    5. The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres. Walfridsson J, et al. Nucleic Acids Res, 2005. PMID 15908586, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. deletion of hrp1 causes accumulation of antisense transcripts and affects nucleosome positioning.
      Title: Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription.
    2. S. pombe lacks ISWI-type remodelers but it has two CHD1-type ATPases, Hrp1 and Hrp3
      Title: CHD1 remodelers regulate nucleosome spacing in vitro and align nucleosomal arrays over gene coding regions in S. pombe.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone chaperone activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication-dependent chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome disassembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in nucleosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in CENP-A containing chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    CENP-A chaperone, CHD family Hrp1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2194821..2199471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019092.3 → NP_593660.1  CENP-A chaperone, CHD family Hrp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593660.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q92369, Q9US25, Q9UU28
      Conserved Domains (6) summary
      cd00024
      Location:209 → 267
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:409 → 555
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:393 → 677
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:703 → 818
      Helicase_C; Helicase conserved C-terminal domain
      pfam00385
      Location:305 → 356
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam08074
      Location:1132 → 1172
      CHDCT2; CHDCT2 (NUC038) domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials