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    set1 histone H3-K4 methyltransferase Set1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538762, updated on 18-Sep-2024

    Summary

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    Official Symbol
    set1
    Official Full Name
    histone H3-K4 methyltransferase Set1
    Primary source
    PomBase:SPCC306.04c
    Locus tag
    SPOM_SPCC306.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    kmt2
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    Genomic context

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    See set1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (412293..415947, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Rab GTPase-binding protein Neighboring gene condensin complex non-SMC subunit Cnd2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene INSIG domain protein Neighboring gene ncRNA Neighboring gene family protein BIG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex. Mikheyeva IV, et al. PLoS Genet, 2014 Oct. PMID 25356590, Free PMC Article
    2. Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Yamada S, et al. Nucleic Acids Res, 2013 Apr 1. PMID 23382177, Free PMC Article
    3. Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Noma K, et al. Proc Natl Acad Sci U S A, 2002 Dec 10. PMID 12193658, Free PMC Article
    4. Suppression of Meiotic Recombination by CENP-B Homologs in Schizosaccharomyces pombe. Johansen P, et al. Genetics, 2015 Nov. PMID 26354768, Free PMC Article
    5. Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase. Lorenz DR, et al. Elife, 2014 Dec 15. PMID 25497836, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we describe the impact of silencing and clustering on the mobility of an endogenous Tf2 element. Deletion of genes such as set1(+) or abp1(+) that both alleviate silencing and clustering, result in a corresponding increase in mobilization. Furthermore, expression of constitutively active Sre1, a transcriptional activator of Tf2 elements, also alleviates clustering and induces mobilization
      Title: Restriction of Retrotransposon Mobilization in Schizosaccharomyces pombe by Transcriptional Silencing and Higher-Order Chromatin Organization.
    2. Heterochromatin assembly and transcriptome repression is mediated by Set1 in coordination with Clr3.
      Title: Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase.
    3. the regulation of Set1 protein level is not coupled to the status of H3K4me or histone H2B ubiquitination by the HULC complex
      Title: Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex.
    4. The results suggest that meiotic DNA double-strand break formation is redundantly regulated by multiple chromatin-related factors including H3K9ac and Set1 in fission yeast.
      Title: Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast.
    5. An unexpected cooperation between Abp1 and the histone H3K4 methyltransferase Set1 was uncovered in regulating sense and antisense transcriptional silencing of Tf2 retrotransposons and Tf body integrity, largely independent of H3K4 methylation.
      Title: CENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons.
    6. trans-histone crosstalk in S. pombe involves direct enhancement of Set1C methyltransferase activity by H2Bub1 and suggest that this represents a conserved aspect of H2Bub1-H3K4me crosstalk in eukaryotes.
      Title: Histone H2B ubiquitylation promotes activity of the intact Set1 histone methyltransferase complex in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K4 trimethyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in retrotransposon silencing by heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in siRNA-independent facultative heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IC
    Inferred by Curator
    more info
    		  
    is_active_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    histone H3-K4 methyltransferase Set1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      412293..415947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022805.3 → NP_587812.1  histone H3-K4 methyltransferase Set1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587812.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Y7R4
      Conserved Domains (7) summary
      smart00317
      Location:783 → 899
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:904 → 920
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG0724
      Location:90 → 226
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG2940
      Location:457 → 920
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12303
      Location:96 → 180
      RRM_spSet1p_like; RNA recognition motif in fission yeast Schizosaccharomyces pombe SET domain-containing protein 1 (spSet1p) and similar proteins
      pfam11764
      Location:641 → 771
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam11767
      Location:279 → 342
      SET_assoc; Histone lysine methyltransferase SET associated
    Nucleotide Protein
    Heading Accession and Version

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