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    YPT35 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856505, updated on 11-Sep-2024

    Summary

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    Official Symbol
    YPT35
    Primary source
    SGD:S000001147
    Locus tag
    YHR105W
    See related
    AllianceGenome:SGD:S000001147; FungiDB:YHR105W; VEuPathDB:YHR105W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity. Located in endosome. Orthologous to human SNX16 (sorting nexin 16). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (324766..325410)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Sbe22p Neighboring gene trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) Neighboring gene thioredoxin-disulfide reductase TRR2 Neighboring gene septin CDC12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Dissection of Vps13 Regulation in Yeast Using Disease Mutations from Human Orthologs. Park JS, et al. Int J Mol Sci, 2021 Jun 8. PMID 34201352, Free PMC Article
    2. A VPS13D spastic ataxia mutation disrupts the conserved adaptor-binding site in yeast Vps13. Dziurdzik SK, et al. Hum Mol Genet, 2020 Mar 13. PMID 31943017, Free PMC Article
    3. Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites. Bean BDM, et al. J Cell Biol, 2018 Oct 1. PMID 30018089, Free PMC Article
    4. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. Yu JW, et al. J Biol Chem, 2001 Nov 23. PMID 11557775
    5. The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae. Grunau S, et al. Biochem J, 2011 Feb 15. PMID 21121900

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ypt35p
    NP_011973.1
    • Endosomal hypothetical protein; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      324766..325410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179235.1 → NP_011973.1  TPA: Ypt35p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011973.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZT13, D3DL55, P38815
      UniProtKB/TrEMBL
      B3LSM0, B5VK40, C7GLZ1, C8Z9P8, G2WFH9, N1P9E9
      Conserved Domains (1) summary
      cd07280
      Location:73 → 209
      PX_YPT35; The phosphoinositide binding Phox Homology domain of the fungal protein YPT35
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38815.1

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