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    THI80 thiamine diphosphokinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854314, updated on 2-Nov-2024

    Summary

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    Official Symbol
    THI80
    Official Full Name
    thiamine diphosphokinase
    Primary source
    SGD:S000005669
    Locus tag
    YOR143C
    See related
    AllianceGenome:SGD:S000005669; FungiDB:YOR143C; VEuPathDB:YOR143C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables thiamine diphosphokinase activity. Involved in thiamine diphosphate biosynthetic process. Located in cytoplasm. Used to study cancer. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See THI80 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (601383..602342, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Gly Neighboring gene Elg1p Neighboring gene Pno1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A constitutive thiamine metabolism mutation, thi80, causing reduced thiamine pyrophosphokinase activity in Saccharomyces cerevisiae. Nishimura H, et al. J Bacteriol, 1991 Apr. PMID 1849514, Free PMC Article
    2. The crystal structure of yeast thiamin pyrophosphokinase. Baker LJ, et al. Structure, 2001 Jun. PMID 11435118
    3. Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinase. Santini S, et al. BMC Struct Biol, 2008 Jul 24. PMID 18652651, Free PMC Article
    4. Isolation and characterization of a thiamin pyrophosphokinase gene, THI80, from Saccharomyces cerevisiae. Nosaka K, et al. J Biol Chem, 1993 Aug 15. PMID 8394343
    5. Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. Nosaka K, et al. J Biol Chem, 1999 Nov 26. PMID 10567383

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiamine diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    thiamine diphosphokinase
    NP_014786.1
    • Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      601383..602342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183562.1 → NP_014786.1  TPA: thiamine diphosphokinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014786.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2K1, P35202
      UniProtKB/TrEMBL
      C7GN80, G2WN16, N1NWN0
      Conserved Domains (1) summary
      COG1564
      Location:38 → 314
      ThiN; Thiamine pyrophosphokinase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35202.1

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