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    OYE2 NADPH dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856584, updated on 4-Aug-2024

    Summary

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    Gene symbol
    OYE2
    Gene description
    NADPH dehydrogenase
    Primary source
    FungiDB:YHR179W
    Locus tag
    YHR179W
    See related
    SGD:S000001222; AllianceGenome:SGD:S000001222; VEuPathDB:YHR179W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables NADPH dehydrogenase activity. Involved in apoptotic process. Located in cytoplasm and nucleus. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OYE2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (462502..463704)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Rof1p Neighboring gene Stb5p Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineering the Enantioselectivity of Yeast Old Yellow Enzyme OYE2y in Asymmetric Reduction of (E/Z)-Citral to (R)-Citronellal. Ying X, et al. Molecules, 2019 Mar 18. PMID 30889828, Free PMC Article
    2. Exploring De Novo metabolic pathways from pyruvate to propionic acid. Stine A, et al. Biotechnol Prog, 2016 Mar. PMID 26821575
    3. Natural allelic variations of Saccharomyces cerevisiae impact stuck fermentation due to the combined effect of ethanol and temperature; a QTL-mapping study. Marullo P, et al. BMC Genomics, 2019 Aug 28. PMID 31462217, Free PMC Article
    4. Engineering the biocatalytic selectivity of iridoid production in Saccharomyces cerevisiae. Billingsley JM, et al. Metab Eng, 2017 Nov. PMID 28939278, Free PMC Article
    5. α,β-Dicarbonyl reduction is mediated by the Saccharomyces Old Yellow Enzyme. van Bergen B, et al. FEMS Yeast Res, 2016 Aug. PMID 27400981

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three Quantitative Trait Loci linked to stuck fermentation in winemaking conditions were identified by using a selective genotyping strategy carried out on a backcrossed population. The precision of mapping allowed the identification of two causative genes VHS1 and OYE2 characterized by stop-codon insertion.
      Title: Natural allelic variations of Saccharomyces cerevisiae impact stuck fermentation due to the combined effect of ethanol and temperature; a QTL-mapping study.
    2. The results point to the stress-related proteins Ahp1, Yhb1 and Oye2, as well as Gln1 and Kes1 as putative candidates for being evaluated as biomarkers for diagnostic assays of S. cerevisiae infections.
      Title: Immunoproteomic profiling of Saccharomyces cerevisiae systemic infection in a murine model.
    3. OYE proteins are firmly placed in the signaling network connecting ROS generation, PCD modulation, and cytoskeletal dynamics in yeast.
      Title: Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentaerythritol trinitrate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADPH dehydrogenase
    NP_012049.1
    • Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      462502..463704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179310.1 → NP_012049.1  TPA: NADPH dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLC8, E9P8V8, Q03558
      UniProtKB/TrEMBL
      A6ZT86, B3LSU1, C7GW80, C8Z9X5, N1P1A6
      Conserved Domains (1) summary
      cd02933
      Location:16 → 372
      OYE_like_FMN; Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03558.3

    Gene LinkOut

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