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    hht2 histone H3 h3.2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541220, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hht2
    Official Full Name
    histone H3 h3.2
    Primary source
    PomBase:SPBC8D2.04
    Locus tag
    SPOM_SPBC8D2.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    h3.2
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    Genomic context

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    See hht2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1365119..1365818)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene histone H4 h4.2 Neighboring gene protein Sfi1 Neighboring gene ncRNA Neighboring gene isoleucine--tRNA(Ile) ligase Irs1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast. Lim KK, et al. Sci Rep, 2015 Sep 15. PMID 26369364, Free PMC Article
    2. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. Dhayalan A, et al. J Biol Chem, 2010 Aug 20. PMID 20547484, Free PMC Article
    3. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Canzio D, et al. Mol Cell, 2011 Jan 7. PMID 21211724, Free PMC Article
    4. Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe. Xhemalce B, et al. J Biol Chem, 2007 May 18. PMID 17369611
    5. Establishment and maintenance of a heterochromatin domain. Hall IM, et al. Science, 2002 Sep 27. PMID 12215653

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Schizosaccharomyces pombe Hst4, a homolog of histone deacetylase Sir2, participates in S-phase-specific DNA damage tolerance; it was required for the deacetylation of histone H3 core domain residue lysine 56.
      Title: Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.
    2. Clr4 abolished the inhibitory effect of histone h3 on the RanGAP activity required for the heterochromatin assembly.
      Title: Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables chromatin-protein adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables chromatin-protein adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of chromatin IC
    Inferred by Curator
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin boundary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolar peripheral inclusion body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone H3 h3.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1365119..1365818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021462.3 → NP_595567.1  histone H3 h3.2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595567.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P09988, P10651
      Conserved Domains (2) summary
      PTZ00018
      Location:1 → 136
      PTZ00018; histone H3; Provisional
      pfam00125
      Location:1 → 132
      Histone; Core histone H2A/H2B/H3/H4
    Nucleotide Protein
    Heading Accession and Version

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