CLB5 B-type cyclin CLB5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CLB5
Gene description: B-type cyclin CLB5
Primary source: FungiDB:YPR120C
Locus tag: YPR120C
See related: SGD:S000006324; AllianceGenome:SGD:S000006324; VEuPathDB:YPR120C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including mitotic cell cycle phase transition; regulation of cell cycle process; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in nucleus. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1) and CCNB2 (cyclin B2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CLB5 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (773875..775182, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The S-Phase Cyclin Clb5 Promotes rRNA Gene (rDNA) Stability by Maintaining Replication Initiation Efficiency in rDNA.
Title: The S-Phase Cyclin Clb5 Promotes rRNA Gene (rDNA) Stability by Maintaining Replication Initiation Efficiency in rDNA.
Cdk1 and multiple cyclins become highly enriched at DSBs and that the recruitment of Cdk1 and cyclins Clb2 and Clb5 ensures optimal Fun30 phosphorylation and checkpoint activation.
Title: Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection.
a novel and unexpected role for Aurora kinase in preventing the formation of spindles by Clb5-CDK (S-CDK) during meiotic prophase I
Title: Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis.
Results suggest that Clb5 has a unique ability to trigger premeiotic S phase and that the amino-terminal region of Clb5 contributes to its specificity and regulates the functions performed by the cyclin-Cdk complex.
Title: Among B-type cyclins only CLB5 and CLB6 promote premeiotic S phase in Saccharomyces cerevisiae.
The lack of Snf1 alpha-catalytic subunit down-regulates CLB5 expression.
Title: Snf1/AMPK promotes S-phase entrance by controlling CLB5 transcription in budding yeast.
These data indicate that Clb5 and Clb6 promote cohesion which is then protected by Pds1 and that both mechanisms are required during replication stress.
Title: S-phase cyclin-dependent kinases promote sister chromatid cohesion in budding yeast.
A model in which TORC1 and Clb5/CDK act coordinately to promote both spindle assembly via a pathway involving Kip3 and S phase progression.
Title: TORC1 kinase and the S-phase cyclin Clb5 collaborate to promote mitotic spindle assembly and DNA replication in S. cerevisiae.
In the presence of replication stress, the unstable Clb5 pool is stabilized, and such stabilization requires neither MBF transcriptional activity nor de novo protein synthesis.
Title: Cyclin regulation by the s phase checkpoint.
Data show that, at early S phase, Hog1 prevents firing of replication origins by delaying the accumulation of the S phase cyclins Clb5 and Clb6.
Title: The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.
The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae
Title: The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-12f9 (e-PCR)
- UniSTS:258319

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic spindle pole body separation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in premeiotic DNA replication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in premeiotic DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic spindle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: B-type cyclin CLB5

NP_015445.1

B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

773875..775182 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184217.1 → NP_015445.1 TPA: B-type cyclin CLB5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015445.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4B9, P30283

UniProtKB/TrEMBL

A0A8H4F9Y7, A6ZX01, B3LK84, C7GLI3, C8ZJE2, N1NXR2

Conserved Domains (1) summary

COG5024
Location:1 → 431

COG5024; Cyclin [Cell division and chromosome partitioning]