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    MDG1 Mdg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855548, updated on 1-Aug-2024

    Summary

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    Gene symbol
    MDG1
    Gene description
    Mdg1p
    Primary source
    FungiDB:YNL173C
    Locus tag
    YNL173C
    See related
    SGD:S000005117; AllianceGenome:SGD:S000005117; VEuPathDB:YNL173C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein kinase binding activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in plasma membrane. Colocalizes with eisosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MDG1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (308957..310057, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Tda7p Neighboring gene Nop13p Neighboring gene anaphase promoting complex subunit 1 Neighboring gene phosphatidylserine decarboxylase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity. Leberer E, et al. Mol Gen Genet, 1996 Oct 16. PMID 8914522
    2. Plasma membrane microdomains regulate turnover of transport proteins in yeast. Grossmann G, et al. J Cell Biol, 2008 Dec 15. PMID 19064668, Free PMC Article
    3. α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast. Popova B, et al. Cells, 2021 Aug 28. PMID 34571878, Free PMC Article
    4. The Hsp70 homolog Ssb and the 14-3-3 protein Bmh1 jointly regulate transcription of glucose repressed genes in Saccharomyces cerevisiae. Hübscher V, et al. Nucleic Acids Res, 2016 Jul 8. PMID 27001512, Free PMC Article
    5. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Aguilar PS, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526336, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mdg1p
    NP_014226.1
    • Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      308957..310057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183011.1 → NP_014226.1  TPA: Mdg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014226.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZRR2, B3LP25, C7GTE8, C8ZG55, D6W111, P53885
      UniProtKB/TrEMBL
      N1NXS2
      Conserved Domains (1) summary
      cd02859
      Location:8 → 87
      E_set_AMPKbeta_like_N; N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53885.1

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