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    abc2 vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543193, updated on 18-Sep-2024

    Summary

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    Official Symbol
    abc2
    Official Full Name
    vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc2
    Primary source
    PomBase:SPAC3F10.11c
    Locus tag
    SPOM_SPAC3F10.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See abc2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2837121..2841788, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. Mendoza-Cózatl DG, et al. J Biol Chem, 2010 Dec 24. PMID 20937798, Free PMC Article
    2. A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant. Iwaki T, et al. Microbiology (Reading), 2006 Aug. PMID 16849797
    3. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
    4. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ABC-type phytochelatin transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione transmembrane import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phytochelatin 2 import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus HDA PubMed 
    is_active_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2837121..2841788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019371.4 → NP_593943.3  vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593943.3

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78928, Q10185
      Conserved Domains (4) summary
      TIGR00957
      Location:96 → 1477
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1237 → 1456
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:593 → 798
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:928 → 1190
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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