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    ELP6 Elongator subunit ELP6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855360, updated on 19-Jun-2024

    Summary

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    Gene symbol
    ELP6
    Gene description
    Elongator subunit ELP6
    Primary source
    FungiDB:YMR312W
    Locus tag
    YMR312W
    See related
    SGD:S000004929; AllianceGenome:SGD:S000004929; VEuPathDB:YMR312W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HAP3; KTI4; TOT6
    Summary
    Contributes to ATP hydrolysis activity and tRNA binding activity. Involved in protein urmylation; regulation of transcription by RNA polymerase II; and tRNA wobble uridine modification. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ELP6 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (898405..899226)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative methyltransferase Neighboring gene Glc8p Neighboring gene bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase Neighboring gene proteasome core particle subunit alpha 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel domains and orthologues of eukaryotic transcription elongation factors. Ponting CP. Nucleic Acids Res, 2002 Sep 1. PMID 12202748, Free PMC Article
    2. Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator. Jablonowski D, et al. Mol Microbiol, 2001 Nov. PMID 11737649
    3. Unfolded Protein Response Suppression in Yeast by Loss of tRNA Modifications. Bruch A, et al. Genes (Basel), 2018 Oct 23. PMID 30360492, Free PMC Article
    4. Crystal structure of elongator subcomplex Elp4-6. Lin Z, et al. J Biol Chem, 2012 Jun 15. PMID 22556426, Free PMC Article
    5. Architecture of the yeast Elongator complex. Dauden MI, et al. EMBO Rep, 2017 Feb. PMID 27974378, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein urmylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongator subunit ELP6
    NP_014043.1
    • Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      898405..899226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182823.1 → NP_014043.1  TPA: Elongator subunit ELP6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0D9, Q04868
      UniProtKB/TrEMBL
      A0A8H4F8G0, A6ZN29, B3LMK0, B5VQ78, C8ZFI3, N1NYW7
      Conserved Domains (1) summary
      cd19479
      Location:32 → 221
      Elp456; Elongator subcomplex subunits Elp4, 5 and 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04868.1

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