uncharacterized protein [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Full Name: uncharacterized protein
Primary source: SGD:S000005078
Locus tag: YNL134C
See related: AllianceGenome:SGD:S000005078; FungiDB:YNL134C; VEuPathDB:YNL134C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables aldehyde dehydrogenase (NAD+) activity. Involved in response to furfural. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

identification and characterization of YNL134C in the biosynthesis of the 4-hydroxy-2(or 5)-ethyl-5(or 2)-methyl-3(2H)-furanone in yeast
Title: Identification and characterization of an enzyme involved in the biosynthesis of the 4-hydroxy-2(or 5)-ethyl-5(or 2)-methyl-3(2H)-furanone in yeast.
YNL134C is a broad-substrate aldehyde reductase, which can reduce multiple aldehydes to their corresponding alcohol.
Title: YNL134C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity for detoxification of furfural derived from lignocellulosic biomass.
YNL134C and YDL124W were also identified as candidate Yap2 target genes.
Title: Candidate target genes for the Saccharomyces cerevisiae transcription factor, Yap2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to furfural	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_014265.3

NADH-dependent aldehyde reductase; involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress