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    ams1 alpha-mannosidase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543485, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ams1
    Official Full Name
    alpha-mannosidase
    Primary source
    PomBase:SPAC513.05
    Locus tag
    SPOM_SPAC513.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mns2
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    Genomic context

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    See ams1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2914479..2920278)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene M-factor precursor Mfm2 Neighboring gene dihydrodiol dehydrogenase Neighboring gene ncRNA Neighboring gene flavonol reductase/cinnamoyl-CoA reductase family Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of fission yeast tetrameric α-mannosidase Ams1. Zhang J, et al. FEBS Open Bio, 2020 Nov. PMID 32981237, Free PMC Article
    2. Characterization of Schizosaccharomyces pombe ER alpha-mannosidase: a reevaluation of the role of the enzyme on ER-associated degradation. Movsichoff F, et al. Mol Biol Cell, 2005 Oct. PMID 16079177, Free PMC Article
    3. Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1. Wang YY, et al. EMBO J, 2021 Aug 2. PMID 34169534, Free PMC Article
    4. Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription. Heo DH, et al. Cell Rep, 2021 Sep 7. PMID 34496258, Free PMC Article
    5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannosyl-oligosaccharide 1,3-alpha-mannosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mannosyl-oligosaccharide 1,6-alpha-mannosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in fungal-type vacuole lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-mannosidase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2914479..2920278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019405.3 → NP_593979.1  alpha-mannosidase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593979.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UT61
      Conserved Domains (4) summary
      cd10812
      Location:282 → 538
      GH38N_AMII_ScAms1_like; N-terminal catalytic domain of yeast vacuolar alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:44 → 1077
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
      pfam07748
      Location:664 → 1073
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:555 → 634
      Alpha-mann_mid; Alpha mannosidase, middle domain
    Nucleotide Protein
    Heading Accession and Version

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