RAM1 protein farnesyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RAM1
Official Full Name: protein farnesyltransferase
Primary source: SGD:S000002248
Locus tag: YDL090C
See related: AllianceGenome:SGD:S000002248; FungiDB:YDL090C; VEuPathDB:YDL090C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DPR1; FUS8; SCG2; SGP2; STE16
Summary: Enables protein farnesyltransferase activity. Involved in protein farnesylation. Part of protein farnesyltransferase complex. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to human CHURC1-FNTB (CHURC1-FNTB readthrough) and FNTB (farnesyltransferase, CAAX box, subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RAM1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (295034..296329, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein farnesyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein farnesyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in protein farnesylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein farnesylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of protein farnesyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein farnesyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein farnesyltransferase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein farnesyltransferase

NP_010193.1

EC 2.5.1.58

Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

295034..296329 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180149.1 → NP_010193.1 TPA: protein farnesyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010193.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRQ8, E9P902, P22007, Q12422

UniProtKB/TrEMBL

A6ZXN7, B3LGY5, C7GJM4, C8Z6L3, N1P7N9

Conserved Domains (1) summary

cd02893
Location:80 → 374

FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...