U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pxl1 paxillin-like protein Pxl1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540856, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pxl1
    Official Full Name
    paxillin-like protein Pxl1
    Primary source
    PomBase:SPBC4F6.12
    Locus tag
    SPOM_SPBC4F6.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pxl1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2712168..2714207)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative guanyl-nucleotide exchange factor Vps901 Neighboring gene asparagine synthase Neighboring gene ncRNA Neighboring gene WD repeat/BOP1NT protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring. Snider CE, et al. Mol Biol Cell, 2022 Apr 1. PMID 35108037, Free PMC Article
    2. Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis. Snider CE, et al. Cell Rep, 2020 Dec 22. PMID 33357436, Free PMC Article
    3. Cooperation between Paxillin-like Protein Pxl1 and Glucan Synthase Bgs1 Is Essential for Actomyosin Ring Stability and Septum Formation in Fission Yeast. Cortés JC, et al. PLoS Genet, 2015 Jul. PMID 26132084, Free PMC Article
    4. DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division. Bhattacharjee R, et al. Mol Biol Cell, 2020 Apr 15. PMID 32101481, Free PMC Article
    5. Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast. Martín-García R, et al. Cell Rep, 2018 Oct 16. PMID 30332655

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.
      Title: Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.
    2. Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.
      Title: Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.
    3. paxillin homologue Pxl1 modulates Rho1 GTPase signaling and plays a role in the formation and contraction of the actomyosin ring during cytokinesis
      Title: Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables F-bar domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables Rho GDP-dissociation inhibitor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actomyosin contractile ring organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to mitotic actomyosin contractile ring IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    paxillin-like protein Pxl1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2712168..2714207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022029.3 → NP_596112.1  paxillin-like protein Pxl1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596112.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74398
      Conserved Domains (2) summary
      cd08368
      Location:378 → 428
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam00412
      Location:258 → 314
      LIM; LIM domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials