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    cpc2 40S ribosomal protein RACK1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543298, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cpc2
    Official Full Name
    40S ribosomal protein RACK1
    Primary source
    PomBase:SPAC6B12.15
    Locus tag
    SPOM_SPAC6B12.15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    rkp1
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    Genomic context

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    See cpc2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (2439511..2441027)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene protein meu26

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast. Núñez A, et al. Mol Biol Cell, 2009 Sep. PMID 19625445, Free PMC Article
    2. Cpc2, a fission yeast homologue of mammalian RACK1 protein, interacts with Ran1 (Pat1) kinase To regulate cell cycle progression and meiotic development. McLeod M, et al. Mol Cell Biol, 2000 Jun. PMID 10805744, Free PMC Article
    3. Rkp1/Cpc2, a fission yeast RACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling. Won M, et al. Biochem Biophys Res Commun, 2001 Mar 23. PMID 11263963
    4. Cpc2/RACK1 is a ribosome-associated protein that promotes efficient translation in Schizosaccharomyces pombe. Shor B, et al. J Biol Chem, 2003 Dec 5. PMID 12972434
    5. Role of the RNA-binding protein Nrd1 in stress granule formation and its implication in the stress response in fission yeast. Satoh R, et al. PLoS One, 2012. PMID 22276125, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe.
      Title: Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe.
    2. S. pombe Cpc2 facilitates the GAAC response through the regulation of Gcn2 activation
      Title: Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.
    3. in fission yeast Cpc2/RACK1 positively regulates from the ribosome the mitotic onset by modulating both the protein levels and the activity of Wee1
      Title: Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.
    4. Cpc2 negatively regulates the cell integrity transduction pathway and positively regulates the synthesis of the stress-responsive transcription factor Atf1 and the cytoplasmic catalase.
      Title: Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.
    5. A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.
      Title: A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GCN2-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell integrity MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translational frameshifting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    40S ribosomal protein RACK1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2439511..2441027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019200.3 → NP_593770.1  40S ribosomal protein RACK1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593770.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78896, Q10281
      Conserved Domains (3) summary
      COG2319
      Location:7 → 310
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:7 → 311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:18 → 61
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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