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    LCL2 Lcl2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850794, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LCL2
    Official Full Name
    Lcl2p
    Primary source
    SGD:S000004094
    Locus tag
    YLR104W
    See related
    AllianceGenome:SGD:S000004094; FungiDB:YLR104W; VEuPathDB:YLR104W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ubiquitin-dependent ERAD pathway. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LCL2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (346585..346980)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 9 Neighboring gene DNA replication initiation factor CDC45 Neighboring gene tRNA splicing endonuclease subunit SEN2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Daughters of the budding yeast from old mothers have shorter replicative lifespans but not total lifespans. Are DNA damage and rDNA instability the factors that determine longevity? Molon M, et al. Cell Cycle, 2018. PMID 29895191, Free PMC Article
    2. Screening for new yeast mutants affected in mannosylphosphorylation of cell wall mannoproteins. Conde R, et al. Yeast, 2003 Oct 30. PMID 14587103
    3. Nuclear pore targeting of the yeast Pom33 nucleoporin depends on karyopherin and lipid binding. Floch AG, et al. J Cell Sci, 2015 Jan 15. PMID 25413348
    4. A microarray-based genetic screen for yeast chronological aging factors. Matecic M, et al. PLoS Genet, 2010 Apr 22. PMID 20421943, Free PMC Article
    5. Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1. Friederichs JM, et al. G3 (Bethesda), 2012 Dec. PMID 23275891, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway HGI PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Lcl2p
    NP_013205.1
    • hypothetical protein; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      346585..346980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181991.1 → NP_013205.1  TPA: Lcl2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013205.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A108, B3LT72, C7GQS7, C8ZD75, D6VYA4, Q08045
      UniProtKB/TrEMBL
      G2WIU7, N1P144
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08045.1

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