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    SGE1 Sge1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856327, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SGE1
    Official Full Name
    Sge1p
    Primary source
    SGD:S000006402
    Locus tag
    YPR198W
    See related
    AllianceGenome:SGD:S000006402; FungiDB:YPR198W; VEuPathDB:YPR198W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NOR1
    Summary
    Enables xenobiotic transmembrane transporter activity. Involved in transmembrane transport. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SGE1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (934034..935665)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative maltose-responsive transcription factor Neighboring gene Arr1p Neighboring gene Arr2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Sge1 protein of Saccharomyces cerevisiae is a membrane-associated multidrug transporter. Ehrenhofer-Murray AE, et al. Yeast, 1998 Jan 15. PMID 9483795
    2. The Saccharomyces cerevisiae MFS superfamily SGE1 gene confers resistance to cationic dyes. Jacquot C, et al. Yeast, 1997 Aug. PMID 9271105
    3. Natural Variation in the Multidrug Efflux Pump SGE1 Underlies Ionic Liquid Tolerance in Yeast. Higgins DA, et al. Genetics, 2018 Sep. PMID 30045857, Free PMC Article
    4. Isolation and characterization of SGE1: a yeast gene that partially suppresses the gal11 mutation in multiple copies. Amakasu H, et al. Genetics, 1993 Jul. PMID 8349103, Free PMC Article
    5. The Saccharomyces cerevisiae SGE1 gene product: a novel drug-resistance protein within the major facilitator superfamily. Ehrenhofer-Murray AE, et al. Mol Gen Genet, 1994 Aug 2. PMID 8058039

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sge1p
    NP_015524.1
    • Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      934034..935665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184295.1 → NP_015524.1  TPA: Sge1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015524.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4J6, P33335, Q05720
      UniProtKB/TrEMBL
      A6ZX70, B3LRH8, B5VTX5, C8ZJM7, N1NW75
      Conserved Domains (1) summary
      cd17502
      Location:24 → 531
      MFS_Azr1_MDR_like; Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33335.1

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