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    SLY41 Sly41p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854484, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SLY41
    Official Full Name
    Sly41p
    Primary source
    SGD:S000005834
    Locus tag
    YOR307C
    See related
    AllianceGenome:SGD:S000005834; FungiDB:YOR307C; VEuPathDB:YOR307C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable antiporter activity and phosphoenolpyruvate transmembrane transporter activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. Orthologous to human SLC35E1 (solute carrier family 35 member E1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SLY41 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (892731..894092, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rrg7p Neighboring gene riboflavin transporter Neighboring gene U4/U6-U5 snRNP complex subunit SNU66 Neighboring gene RNA-processing protein NOP58

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and analysis of a 36.2 kb fragment from the right arm of yeast chromosome XV reveals 19 open reading frames including SNF2 (5' end), CPA1, SLY41, a putative transport ATPase, a putative ribosomal protein and an SNF2 homologue. Poirey R, et al. Yeast, 1997 Apr. PMID 9153758
    2. Overexpression of Sly41 suppresses COPII vesicle-tethering deficiencies by elevating intracellular calcium levels. Mukherjee I, et al. Mol Biol Cell, 2016 May 15. PMID 27030673, Free PMC Article
    3. Calcium and SLY genes suppress the temperature-sensitive secretion defect of Saccharomyces cerevisiae uso1 mutant. Kito M, et al. Biochem Biophys Res Commun, 1996 Mar 27. PMID 8607820
    4. Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Dascher C, et al. Mol Cell Biol, 1991 Feb. PMID 1990290, Free PMC Article
    5. The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport. Ossig R, et al. Mol Cell Biol, 1991 Jun. PMID 1903839, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphoenolpyruvate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate transmembrane import into Golgi lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sly41p
    NP_014952.1
    • Protein involved in ER-to-Golgi transport; packaged into COPII vesicles for trafficking between ER and Golgi

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      892731..894092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183727.1 → NP_014952.1  TPA: Sly41p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014952.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W307, P22215
      UniProtKB/TrEMBL
      A6ZPE3, B3LJX2, B5VSI4, C7GNV3, C8ZH58, G2WNH4, N1NWZ2
      Conserved Domains (1) summary
      TIGR00817
      Location:112 → 451
      tpt; Tpt phosphate/phosphoenolpyruvate translocator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22215.2

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