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    pyr1 pyruvate carboxylase Pyr1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539661, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pyr1
    Official Full Name
    pyruvate carboxylase Pyr1
    Primary source
    PomBase:SPBC17G9.11c
    Locus tag
    SPOM_SPBC17G9.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pyr1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2190645..2194537, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF2 gamma subunit tif213 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein uL5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hydrolase Neighboring gene ncRNA Neighboring gene protein cup1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast. Mathiassen SG, et al. J Biol Chem, 2015 Aug 21. PMID 26152728, Free PMC Article
    2. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
    3. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
    4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in generation of precursor metabolites and energy NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    pyruvate carboxylase Pyr1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2190645..2194537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021807.3 → NP_595900.1  pyruvate carboxylase Pyr1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595900.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78822, Q9UUE1
      Conserved Domains (7) summary
      cd06850
      Location:1116 → 1182
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd07937
      Location:572 → 854
      DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
      smart00878
      Location:373 → 480
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      COG1038
      Location:27 → 1184
      PycA; Pyruvate carboxylase [Energy production and conversion]
      pfam00289
      Location:33 → 144
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02436
      Location:865 → 1064
      PYC_OADA; Conserved carboxylase domain
      cl17255
      Location:149 → 356
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version

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