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    CYT2 cytochrome c1 heme lyase CYT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853775, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CYT2
    Official Full Name
    cytochrome c1 heme lyase CYT2
    Primary source
    SGD:S000001570
    Locus tag
    YKL087C
    See related
    AllianceGenome:SGD:S000001570; FungiDB:YKL087C; VEuPathDB:YKL087C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables holocytochrome-c synthase activity. Involved in cytochrome c-heme linkage. Located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CYT2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (277189..277863, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mif2p Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit CAB3 Neighboring gene sulfiredoxin Neighboring gene malate dehydrogenase MDH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase. Zollner A, et al. Eur J Biochem, 1992 Aug 1. PMID 1499554
    2. Expression of the Saccharomyces cerevisiae CYT2 gene, encoding cytochrome c1 heme lyase. Zollner A, et al. Curr Genet, 1994 Apr. PMID 8082171
    3. Heme binding to a conserved Cys-Pro-Val motif is crucial for the catalytic function of mitochondrial heme lyases. Steiner H, et al. J Biol Chem, 1996 Dec 20. PMID 8955088
    4. Biogenesis of mitochondrial heme lyases in yeast. Import and folding in the intermembrane space. Steiner H, et al. J Biol Chem, 1995 Sep 29. PMID 7559417
    5. On the specificity of cytochrome c synthetase in recognition of the amino acid sequence of apocytochrome c. Visco C, et al. J Biol Chem, 1985 May 25. PMID 2987215

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables holocytochrome-c synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables holocytochrome-c synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables holocytochrome-c synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytochrome c-heme linkage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c1 heme lyase CYT2
    NP_012836.1
    • Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      277189..277863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179653.1 → NP_012836.1  TPA: cytochrome c1 heme lyase CYT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012836.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXK1, Q00873
      UniProtKB/TrEMBL
      A6ZZN1, B3LR05, B5VM71, C7GVM3, C8ZC87, G2WHU6
      Conserved Domains (1) summary
      pfam01265
      Location:57 → 218
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00873.1

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