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    ADH7 NADP-dependent alcohol dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850469, updated on 1-Aug-2024

    Summary

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    Gene symbol
    ADH7
    Gene description
    NADP-dependent alcohol dehydrogenase
    Primary source
    FungiDB:YCR105W
    Locus tag
    YCR105W
    See related
    SGD:S000000702; AllianceGenome:SGD:S000000702; VEuPathDB:YCR105W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ADHVII
    Summary
    Enables alcohol dehydrogenase (NADP+) activity. Involved in alcohol metabolic process. Orthologous to human ZADH2 (zinc binding alcohol dehydrogenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ADH7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (309070..310155)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene seripauperin PAU3 Neighboring gene Rds1p Neighboring gene putative aryl-alcohol dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast ADH7 promoter enables gene expression under pronounced translation repression caused by the combined stress of vanillin, furfural, and 5-hydroxymethylfurfural. Ishida Y, et al. J Biotechnol, 2017 Jun 20. PMID 28458045
    2. 5-Hydroxymethylfurfural induces ADH7 and ARI1 expression in tolerant industrial Saccharomyces cerevisiae strain P6H9 during bioethanol production. Sehnem NT, et al. Bioresour Technol, 2013 Apr. PMID 23422309
    3. Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase. Buchhaupt M, et al. Appl Microbiol Biotechnol, 2012 Jan. PMID 21789493
    4. Characterization of a Saccharomyces cerevisiae NADP(H)-dependent alcohol dehydrogenase (ADHVII), a member of the cinnamyl alcohol dehydrogenase family. Larroy C, et al. Eur J Biochem, 2002 Nov. PMID 12423374
    5. The VFH1 (YLL056C) promoter is vanillin-inducible and enables mRNA translation despite pronounced translation repression caused by severe vanillin stress in Saccharomyces cerevisiae. Nguyen TTM, et al. Yeast, 2018 Jul. PMID 29575020

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-methylbutanal reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cinnamyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alcohol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alcohol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent alcohol dehydrogenase
    NP_010030.1
    • NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      309070..310155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178812.1 → NP_010030.1  TPA: NADP-dependent alcohol dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010030.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRA5, P25377
      UniProtKB/TrEMBL
      A6ZTC9, B3LNN9, B5VF32, C8ZAZ5
      Conserved Domains (1) summary
      cd05283
      Location:8 → 353
      CAD1; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25377.1

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