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    cut2 securin cut2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539641, updated on 10-Oct-2024

    Summary

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    Official Symbol
    cut2
    Official Full Name
    securin cut2
    Primary source
    PomBase:SPBC14C8.01c
    Locus tag
    SPOM_SPBC14C8.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC1815.02c
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    Genomic context

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    See cut2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2203000..2204216, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene enolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TIM23 translocase complex subunit Tim44

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase. Vijayakumari D, et al. Cell Rep, 2022 Mar 22. PMID 35320724, Free PMC Article
    2. Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase. Nagao K, et al. Genes Cells, 2006 Mar. PMID 16483313
    3. Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin. Yanagida M. Genes Cells, 2000 Jan. PMID 10651900
    4. Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis. Kumada K, et al. Curr Biol, 1998 May 21. PMID 9635190
    5. Cut2 proteolysis required for sister-chromatid seperation in fission yeast. Funabiki H, et al. Nature, 1996 May 30. PMID 8632802

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of separase-securin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    securin cut2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2203000..2204216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021811.4 → NP_595904.3  securin cut2 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN2L421
    Nucleotide Protein
    Heading Accession and Version

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