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    MTC6 Mtc6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856556, updated on 29-Jun-2024

    Summary

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    Gene symbol
    MTC6
    Gene description
    Mtc6p
    Primary source
    FungiDB:YHR151C
    Locus tag
    YHR151C
    See related
    SGD:S000001194; AllianceGenome:SGD:S000001194; VEuPathDB:YHR151C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MTC6 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (399268..400848, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Skg6p Neighboring gene Pex28p Neighboring gene Spo12p Neighboring gene Spo16p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Papinski D, et al. Mol Cell, 2014 Feb 6. PMID 24440502, Free PMC Article
    2. Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid. Desmoucelles C, et al. J Biol Chem, 2002 Jul 26. PMID 12016207
    3. Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. Michaillat L, et al. PLoS One, 2013. PMID 23383298, Free PMC Article
    4. New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1. Cocklin R, et al. Genetics, 2011 Mar. PMID 21196523, Free PMC Article
    5. Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Ruotolo R, et al. Genome Biol, 2008 Apr 7. PMID 18394190, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydrostatic pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mtc6p
    NP_012021.1
    • ER-resident glycoprotein involved in high-pressure tolerance; proposed role promoting proper folding of nutrient permeases in the ER during hydrostatic pressure stress; contains two transmembrane domains, a C-terminal cytoplasmic domain and a luminal region containing 12 N-linked glycans; null mutant is synthetically sick with cdc13-1; SWAT-GFP and mCherry fusion proteins localize to the vacuole while SWAT-GFP fusion also localizes to the endoplasmic reticulum

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      399268..400848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179282.1 → NP_012021.1  TPA: Mtc6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZT59, B3LSR5, B5VK80, C8Z9U8, D3DLA0, P38849
      UniProtKB/TrEMBL
      A0A8H4C288, G2WFM4, N1P9G6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38849.1

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