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    MXR2 peptide-methionine (R)-S-oxide reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850324, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MXR2
    Official Full Name
    peptide-methionine (R)-S-oxide reductase
    Primary source
    SGD:S000000538
    Locus tag
    YCL033C
    See related
    AllianceGenome:SGD:S000000538; FungiDB:YCL033C; VEuPathDB:YCL033C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables peptide-methionine (R)-S-oxide reductase activity. Involved in cellular response to oxidative stress. Located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to several human genes including MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MXR2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (62776..63282, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene dithiol glutaredoxin GRX1 Neighboring gene Lsb5p Neighboring gene Ste50p Neighboring gene Rrp7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reverse genetic approaches in plants and yeast suggest a role for novel, evolutionarily conserved, selenoprotein-related genes in oxidative stress defense. Rodrigo MJ, et al. Mol Genet Genomics, 2002 Jul. PMID 12172800
    2. CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function. Fomenko DE, et al. Protein Sci, 2002 Oct. PMID 12237451, Free PMC Article
    3. Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Koc A, et al. Proc Natl Acad Sci U S A, 2004 May 25. PMID 15141092, Free PMC Article
    4. A conserved R type Methionine Sulfoxide Reductase reverses oxidized GrpEL1/Mge1 to regulate Hsp70 chaperone cycle. Allu PK, et al. Sci Rep, 2018 Feb 9. PMID 29426933, Free PMC Article
    5. Methionine sulfoxide reductase 2 regulates Cvt autophagic pathway by altering the stability of Atg19 and Ape1 in Saccharomyces cerevisiae. Chatterjee A, et al. J Biol Chem, 2024 Mar. PMID 38246354, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors conclude that the Mxr2-Mge1-Hsp70 protein triad is finely regulated through structural alterations of Mge1 mediated by redox levels.
      Title: Adaptation of Mge1 to oxidative stress by local unfolding and altered Interaction with mitochondrial Hsp70 and Mxr2.
    2. Mxr2 regulates Mge1 by selectively reducing methionine sulfoxide at position 155 and restores the activity of Mge1 both in vitro and in vivo.
      Title: Methionine sulfoxide reductase 2 reversibly regulates Mge1, a cochaperone of mitochondrial Hsp70, during oxidative stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptide-methionine (R)-S-oxide reductase
    NP_009897.1
    • Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      62776..63282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178678.1 → NP_009897.1  TPA: peptide-methionine (R)-S-oxide reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQY2, P25566
      UniProtKB/TrEMBL
      A6ZTF7, B3LU49, C7GSZ0, C8Z456, G2W9Z2, N1P7S1
      Conserved Domains (1) summary
      COG0229
      Location:31 → 168
      MsrB; Peptide methionine sulfoxide reductase MsrB [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25566.1

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