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    GIR2 Gir2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851730, updated on 7-Jul-2024

    Summary

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    Gene symbol
    GIR2
    Gene description
    Gir2p
    Primary source
    FungiDB:YDR152W
    Locus tag
    YDR152W
    See related
    SGD:S000002559; AllianceGenome:SGD:S000002559; VEuPathDB:YDR152W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cytoplasmic translation and positive regulation of cellular response to amino acid starvation. Located in cytoplasm. Part of polysome. Orthologous to human RWDD1 (RWD domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GIR2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (765706..766503)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Num1p Neighboring gene putative mRNA-binding protein CTH1 Neighboring gene Ent5p Neighboring gene peptidylprolyl isomerase CPR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gir2 is an intrinsically unstructured protein that is present in Saccharomyces cerevisiae as a group of heterogeneously electrophoretic migrating forms. Alves VS, et al. Biochem Biophys Res Commun, 2005 Jul 1. PMID 15896712
    2. Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior. Alves VS, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715270
    3. Proteomic analysis reveals complex metabolic regulation in Saccharomyces cerevisiae cells against multiple inhibitors stress. Lv YJ, et al. Appl Microbiol Biotechnol, 2014 Mar. PMID 24442506
    4. Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation. Ishikawa K, et al. Genes Cells, 2013 Oct. PMID 23899355
    5. Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Wout PK, et al. Eukaryot Cell, 2009 Jul. PMID 19448108, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that Rbg2/Gir2 complex is a modulator that maintains cellular homoeostasis, thus promoting the survival of eukaryotic organisms in stressful environments.
      Title: Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation.
    2. Additionally, we describe that the endogenous yeast Gir2 shows heterogeneous electrophoretic mobility, which is not due to proteolytic cleavage.
      Title: Gir2 is an intrinsically unstructured protein that is present in Saccharomyces cerevisiae as a group of heterogeneously electrophoretic migrating forms.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cellular response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Gir2p
    NP_010436.3
    • Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and binds translational activator Gcn1p in dose-dependent manner according to stress level; associates with translating ribosomes; intrinsically unstructured protein whose stability is enhanced upon binding Rbg2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      765706..766503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180459.3 → NP_010436.3  TPA: Gir2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010436.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSD4, Q03768
      UniProtKB/TrEMBL
      A0A6A5PZL3, A6ZYB2, B3LGD0, B5VG47, C7GX34, C8Z567, G2WAQ2, N1P6P3
      Conserved Domains (1) summary
      pfam05773
      Location:5 → 154
      RWD; RWD domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03768.1

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