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    YSR3 sphinganine kinase YSR3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853927, updated on 18-Sep-2024

    Summary

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    Official Symbol
    YSR3
    Official Full Name
    sphinganine kinase YSR3
    Primary source
    SGD:S000001761
    Locus tag
    YKR053C
    See related
    AllianceGenome:SGD:S000001761; FungiDB:YKR053C; VEuPathDB:YKR053C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LBP2
    Summary
    Enables sphingosine-1-phosphate phosphatase activity. Involved in phospholipid dephosphorylation and sphingolipid biosynthetic process. Located in endoplasmic reticulum. Orthologous to human SGPP1 (sphingosine-1-phosphate phosphatase 1) and SGPP2 (sphingosine-1-phosphate phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YSR3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (534067..535281, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Hfl1p Neighboring gene Fe(2+) transporter Neighboring gene dynein heavy chain Neighboring gene Rho family GTPase RHO4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging. Mao C, et al. Methods Enzymol, 2000. PMID 10563329
    2. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Mao C, et al. Biochem J, 1999 Sep 15. PMID 10477278, Free PMC Article
    3. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. Mao C, et al. J Biol Chem, 1997 Nov 7. PMID 9353337
    4. Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. Watanabe R, et al. J Biol Chem, 2002 Dec 20. PMID 12393888
    5. Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Mandala SM, et al. Proc Natl Acad Sci U S A, 1998 Jan 6. PMID 9419344, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dihydrosphingosine-1-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sphinganine kinase YSR3
    NP_012979.3
    • Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      534067..535281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179843.3 → NP_012979.3  TPA: sphinganine kinase YSR3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012979.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXB4, P23501
      UniProtKB/TrEMBL
      A7A013, C7GNL2, C8ZCL7, N1P2Q5
      Conserved Domains (1) summary
      cd03388
      Location:77 → 231
      PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23501.2

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