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    MET13 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852752, updated on 11-Sep-2024

    Summary

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    Official Symbol
    MET13
    Primary source
    SGD:S000003093
    Locus tag
    YGL125W
    See related
    AllianceGenome:SGD:S000003093; FungiDB:YGL125W; VEuPathDB:YGL125W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MET11; MRPL45
    Summary
    Enables methylenetetrahydrofolate reductase (NAD(P)H) activity. Involved in methionine biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (272520..274322)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mediator complex subunit SOH1 Neighboring gene Scs3p Neighboring gene Mon1p Neighboring gene ribosomal 40S subunit protein S2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of S-adenosylmethionine levels in Saccharomyces cerevisiae. Chan SY, et al. J Biol Chem, 2003 Oct 31. PMID 12937179
    2. Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo. Roje S, et al. J Biol Chem, 2002 Feb 8. PMID 11729203
    3. Identification of a putative methylenetetrahydrofolate reductase by sequence analysis of a 6.8 kb DNA fragment of yeast chromosome VII. Tizon B, et al. Yeast, 1996 Sep. PMID 8896269
    4. Isolation of single yeast cells by optical trapping. Grimbergen JA, et al. Yeast, 1993 Jul. PMID 8368006
    5. Discovery of 17 conserved structural RNAs in fungi. Gao W, et al. Nucleic Acids Res, 2021 Jun 21. PMID 34086938, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate reductase (NAD(P)H) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate reductase (NAD(P)H) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylenetetrahydrofolate reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methionine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    methylenetetrahydrofolate reductase (NAD(P)H) MET13
    NP_011390.2
    • Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      272520..274322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180990.1 → NP_011390.2  TPA: methylenetetrahydrofolate reductase (NAD(P)H) MET13 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011390.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU23, O94090, P53128, Q92318
      UniProtKB/TrEMBL
      A6ZU57, B3LHI5, C7GX60, C8Z8C5, N1P5B8
      Conserved Domains (1) summary
      cl00246
      Location:19 → 586
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53128.2

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