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    MTE1 Mte1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852933, updated on 17-May-2024

    Summary

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    Gene symbol
    MTE1
    Gene description
    Mte1p
    Primary source
    FungiDB:YGR042W
    Locus tag
    YGR042W
    See related
    SGD:S000003274; AllianceGenome:SGD:S000003274; VEuPathDB:YGR042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in negative regulation of telomere maintenance and positive regulation of helicase activity. Located in chromosome, telomeric region and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MTE1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (579476..580291)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitogen-activated serine/threonine-protein kinase KSS1 Neighboring gene Bud9p Neighboring gene sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1 Neighboring gene Rme1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. Xue X, et al. Genes Dev, 2016 Mar 15. PMID 26966246, Free PMC Article
    2. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Silva S, et al. Genes Dev, 2016 Mar 15. PMID 26966248, Free PMC Article
    3. The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability. Bernal M, et al. DNA Repair (Amst), 2019 Oct. PMID 31569000
    4. A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Askree SH, et al. Proc Natl Acad Sci U S A, 2004 Jun 8. PMID 15161972, Free PMC Article
    5. Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis. Wild P, et al. Mol Cell, 2019 Aug 22. PMID 31351878, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mte1p
    NP_011556.1
    • hypothetical protein; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      579476..580291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181171.1 → NP_011556.1  TPA: Mte1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011556.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUI0, P53227
      UniProtKB/TrEMBL
      B3LIH9, C7GXM8, C8Z8T8, N1P5Q6
      Conserved Domains (1) summary
      pfam10382
      Location:5 → 88
      DUF2439; Protein of unknown function (DUF2439)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53227.1

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