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    spt6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541605, updated on 11-Sep-2024

    Summary

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    Official Symbol
    spt6
    Primary source
    PomBase:SPAC1F7.01c
    Locus tag
    SPOM_SPAC1F7.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAC694.07c
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4212476..4216861, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS25 Neighboring gene claspin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Has1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast. DeGennaro CM, et al. Mol Cell Biol, 2013 Dec. PMID 24100010, Free PMC Article
    2. Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3. Kato H, et al. Sci Rep, 2013. PMID 23851719, Free PMC Article
    3. Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. Kiely CM, et al. Mol Cell Biol, 2011 Oct. PMID 21844224, Free PMC Article
    4. Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast. Choi ES, et al. PLoS Genet, 2012 Sep. PMID 23028377, Free PMC Article
    5. A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation. Gopalakrishnan R, et al. Nucleic Acids Res, 2019 May 7. PMID 30793188, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions.
      Title: The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions.
    2. A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
      Title: A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
    3. Spt6 and its binding partner, Iws1, are required for heterochromatic silencing in Schizosaccharomyces pombe.
      Title: Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables H3-H4 histone complex chaperone activity IC
    Inferred by Curator
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    part_of pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor Spt6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4212476..4216861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019916.3 → NP_594487.2  transcription elongation factor Spt6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594487.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09915, Q9P7T3
      UniProtKB/TrEMBL
      S6BMF4, S6BSK0
      Conserved Domains (11) summary
      cd09918
      Location:1166 → 1256
      SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
      cd09928
      Location:1266 → 1355
      SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
      COG2183
      Location:294 → 1188
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
      pfam14639
      Location:683 → 821
      YqgF; Holliday-junction resolvase-like of SPT6
      pfam05756
      Location:21 → 65
      S-antigen; S-antigen protein
      pfam14632
      Location:53 → 133
      SPT6_acidic; Acidic N-terminal SPT6
      pfam14633
      Location:1142 → 1354
      SH2_2; SH2 domain
      pfam14635
      Location:822 → 925
      HHH_7; Helix-hairpin-helix motif
      pfam14641
      Location:281 → 394
      HTH_44; Helix-turn-helix DNA-binding domain of SPT6
      pfam14878
      Location:935 → 1042
      DLD; Death-like domain of SPT6
      cl09927
      Location:1050 → 1118
      S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
    Nucleotide Protein
    Heading Accession and Version

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