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    RRP9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856255, updated on 11-Sep-2024

    Summary

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    Official Symbol
    RRP9
    Primary source
    SGD:S000006341
    Locus tag
    YPR137W
    See related
    AllianceGenome:SGD:S000006341; FungiDB:YPR137W; VEuPathDB:YPR137W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U3 snoRNA binding activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of box C/D RNP complex and small-subunit processome. Orthologous to human RRP9 (ribosomal RNA processing 9, U3 small nucleolar RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (802359..804080)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mss18p Neighboring gene chromatin-binding protein CTF4 Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-Asn

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Rrp9p is an evolutionarily conserved U3 snoRNP protein essential for early pre-rRNA processing cleavages and requires box C for its association. Venema J, et al. RNA, 2000 Nov. PMID 11105764, Free PMC Article
    2. Structural and functional analysis of the U3 snoRNA binding protein Rrp9. Zhang L, et al. RNA, 2013 May. PMID 23509373, Free PMC Article
    3. Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. Tauber E, et al. J Biol Chem, 2011 Jan 7. PMID 21044956, Free PMC Article
    4. Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair. Cléry A, et al. Mol Cell Biol, 2007 Feb. PMID 17145781, Free PMC Article
    5. Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly. Rothé B, et al. Nucleic Acids Res, 2017 Jul 7. PMID 28505348, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study etermined the functional interactions between Rrp9, other SSU-processome components and the 5'-terminal region of U3 in yeast pre-rRNA processing. The results identified a crucial amino acid at the surface of the Rrp9 beta-propeller, a protein-protein interaction network and roles for key segments of the U3 5'-terminal region.
      Title: Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA.
    2. conserved 7bc loop is crucial for specific recognition of U3, nucleolar localization of Rrp9, and yeast growth. N-terminal region of Rrp9 contains a bipartite nuclear localization signal that is dispensable for nucleolar localization.
      Title: Structural and functional analysis of the U3 snoRNA binding protein Rrp9.
    3. Sequence and structure requirements for efficient association of Rrp9p on the B/C motif were studied in yeast cells by expression of variant U3 snoRNAs and immunoselection assays.
      Title: Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables U3 snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U3 snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of box C/D methylation guide snoRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rrp9p
    NP_015463.1
    • Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processome; ortholog of the human U3-55k protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      802359..804080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184234.1 → NP_015463.1  TPA: Rrp9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015463.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4D3, Q06506
      UniProtKB/TrEMBL
      A6ZX14, B3LK98, B5VTS4, C7GLJ7, C8ZJG0, N1NXT2
      Conserved Domains (2) summary
      sd00039
      Location:239 → 278
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:233 → 500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06506.1

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