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    YKT6 palmitoyltransferase YKT6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853638, updated on 18-Sep-2024

    Summary

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    Official Symbol
    YKT6
    Official Full Name
    palmitoyltransferase YKT6
    Primary source
    SGD:S000001679
    Locus tag
    YKL196C
    See related
    AllianceGenome:SGD:S000001679; FungiDB:YKL196C; VEuPathDB:YKL196C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNAP receptor activity and palmitoyltransferase activity. Involved in Golgi vesicle transport and organelle fusion. Located in several cellular components, including Golgi apparatus; endosome; and fungal-type vacuole. Part of SNARE complex. Orthologous to human YKT6 (YKT6 v-SNARE homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YKT6 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (74932..75534, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene AAA family ATPase peroxin 1 Neighboring gene tRNA-Asn Neighboring gene Mia40p Neighboring gene threonine--tRNA ligase MST1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding. Pylypenko O, et al. J Mol Biol, 2008 Apr 11. PMID 18329045
    2. The SNARE Ykt6 is released from yeast vacuoles during an early stage of fusion. Dietrich LE, et al. EMBO Rep, 2005 Mar. PMID 15723044, Free PMC Article
    3. Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome-vacuole fusion. Bas L, et al. J Cell Biol, 2018 Oct 1. PMID 30097514, Free PMC Article
    4. Probing protein palmitoylation at the yeast vacuole. Meiringer CT, et al. Methods, 2006 Oct. PMID 17012029
    5. On the mechanism of protein palmitoylation. Dietrich LE, et al. EMBO Rep, 2004 Nov. PMID 15520806, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Different conformational dynamics of SNARE protein Ykt6 among yeast and mammals.
      Title: Different conformational dynamics of SNARE protein Ykt6 among yeast and mammals.
    2. Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex.
      Title: Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex.
    3. A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles.
      Title: A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles.
    4. These findings shed new light on the mechanism of autophagosome-vacuole fusion and reveal that the R-SNARE Ykt6 is required for this process.
      Title: Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome-vacuole fusion.
    5. Data indicate the binding kinetic properties of three SNAREs: Sec22p, Ykt6p and Sso2p.
      Title: Analysis of interactions between SNARE proteins using imaging ellipsometer coupled with microfluidic array.
    6. Observations support a previously suggested closed conformation of cytosolic Ykt6, where the C-terminal farnesyl moiety folds onto a hydrophobic groove in the N-terminal longin domain.
      Title: Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.
    7. Ykt6 is released from membranes by depalmitoylation
      Title: The SNARE Ykt6 is released from yeast vacuoles during an early stage of fusion.
    8. during vacuole fusion, Nyv1 is the classical R-SNARE, whereas the Ykt6-containing complex has a novel function in Vac8 palmitoylation
      Title: ATP-independent control of Vac8 palmitoylation by a SNARE subcomplex on yeast vacuoles.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome-lysosome fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in bounding membrane of organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase YKT6
    NP_012725.1
    • Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within Golgi, endocytic trafficking to vacuole, and vacuolar fusion; membrane localization due to prenylation at carboxy-terminus; targeted to vacuole via AP-3 pathway; human homolog YKT6 can complement yeast ykt6 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      74932..75534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179762.1 → NP_012725.1  TPA: palmitoyltransferase YKT6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012725.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX04, P36015
      UniProtKB/TrEMBL
      A6ZZC9, B3LQQ9, B5VLW8, C7GJ13, C8ZBY0, G2WHJ6, N1P0I2
      Conserved Domains (1) summary
      COG5143
      Location:3 → 200
      SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36015.1

    Gene LinkOut

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