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    rst2 DNA-binding transcription factor, glucose starvation sensing, Rst2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543031, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rst2
    Official Full Name
    DNA-binding transcription factor, glucose starvation sensing, Rst2
    Primary source
    PomBase:SPAC6F12.02
    Locus tag
    SPOM_SPAC6F12.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rst2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1309681..1313429)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene AAA family ATPase involved in ubiquitin-mediated protein degradation Cdc48 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SNARE Stx8 Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe. Jiang G, et al. Mol Microbiol, 2021 Jun. PMID 33400299
    2. Possible involvement of nitric oxide and reactive oxygen species in glucose deprivation-induced activation of transcription factor rst2. Kato T, et al. PLoS One, 2013. PMID 24155978, Free PMC Article
    3. Expression of Mug14 is regulated by the transcription factor Rst2 through the cAMP-dependent protein kinase pathway in Schizosaccharomyces pombe. Inamura SI, et al. Curr Genet, 2021 Oct. PMID 34086083
    4. Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription. Koda W, et al. Nucleic Acids Res, 2021 Sep 27. PMID 34486060, Free PMC Article
    5. Overexpression of the transcription factor Rst2 in Schizosaccharomyces pombe indicates growth defect, mitotic defects, and microtubule disorder. Takenaka K, et al. Biosci Biotechnol Biochem, 2018 Feb. PMID 29316864

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of Mug14 is regulated by the transcription factor Rst2 through the cAMP-dependent protein kinase pathway in Schizosaccharomyces pombe.
      Title: Expression of Mug14 is regulated by the transcription factor Rst2 through the cAMP-dependent protein kinase pathway in Schizosaccharomyces pombe.
    2. Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription.
      Title: Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription.
    3. Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.
      Title: Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.
    4. Rst2 is involved in cellular events such as regulation of cell growth, cell morphology, mitosis progression, microtubules structure, nuclear structure, and stress response
      Title: Overexpression of the transcription factor Rst2 in Schizosaccharomyces pombe indicates growth defect, mitotic defects, and microtubule disorder.
    5. a novel regulation mechanism of Rst2 transcription factor binding through a local genome loop structure.
      Title: Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.
    6. Nitric oxide and reactive oxygen species may be involved in the activation of transcription factor Rst2.
      Title: Possible involvement of nitric oxide and reactive oxygen species in glucose deprivation-induced activation of transcription factor rst2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcription factor, glucose starvation sensing, Rst2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1309681..1313429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018718.3 → NP_593288.1  DNA-binding transcription factor, glucose starvation sensing, Rst2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593288.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78871, Q9USD1
      Conserved Domains (4) summary
      COG5048
      Location:37 → 547
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:72 → 92
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:70 → 92
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:84 → 116
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials