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    cwf5 Prp19 complex subunit, RNA-binding Cwf5 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538974, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cwf5
    Official Full Name
    Prp19 complex subunit, RNA-binding Cwf5
    Primary source
    PomBase:SPCC550.02c
    Locus tag
    SPOM_SPCC550.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ecm2
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    Genomic context

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    See cwf5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003421.2 (1186393..1187622, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene THO complex subunit Tho1 Neighboring gene respiratory chain complex assembly protein Neighboring gene ncRNA Neighboring gene Ski complex RNA helicase Ski2 Neighboring gene ncRNA Neighboring gene pig-C family GPI synthesis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing. McDonald WH, et al. Mol Cell Biol, 1999 Aug. PMID 10409726, Free PMC Article
    2. Characterization of interactions among the Cef1p-Prp19p-associated splicing complex. Ohi MD, et al. RNA, 2002 Jun. PMID 12088152, Free PMC Article
    3. The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast. Aronica L, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26682798, Free PMC Article
    4. Structure of a yeast spliceosome at 3.6-angstrom resolution. Yan C, et al. Science, 2015 Sep 11. PMID 26292707
    5. Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe. Cipakova I, et al. Cell Cycle, 2019 Jul. PMID 31219728, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Prp19 complex subunit, RNA-binding Cwf5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1186393..1187622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023085.2 → NP_588094.1  Prp19 complex subunit, RNA-binding Cwf5 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588094.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59800, Q9USC0
      Conserved Domains (2) summary
      COG0724
      Location:141 → 335
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:210 → 285
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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