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    ERG29 Erg29p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855164, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ERG29
    Official Full Name
    Erg29p
    Primary source
    SGD:S000004741
    Locus tag
    YMR134W
    See related
    AllianceGenome:SGD:S000004741; FungiDB:YMR134W; VEuPathDB:YMR134W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ergosterol biosynthetic process; intracellular iron ion homeostasis; and mitochondrion organization. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ERG29 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (537838..538551)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Jlp2p Neighboring gene Rec114p Neighboring gene glucose-induced degradation complex subunit GID8 Neighboring gene Gat2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The essential gene YMR134W from Saccharomyces cerevisiae is important for appropriate mitochondrial iron utilization and the ergosterol biosynthetic pathway. Moretti-Almeida G, et al. FEBS Lett, 2013 Sep 17. PMID 23892078
    2. Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Altmann K, et al. Mol Biol Cell, 2005 Nov. PMID 16135527, Free PMC Article
    3. Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin. Babcock M, et al. Science, 1997 Jun 13. PMID 9180083
    4. Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis. Ward DM, et al. J Biol Chem, 2018 Jul 6. PMID 29773647, Free PMC Article
    5. FACT interacts with Set3 HDAC and fine-tunes GAL1 transcription in response to environmental stimulation. Leng H, et al. Nucleic Acids Res, 2021 Jun 4. PMID 33963860, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope HDA PubMed 

    General protein information

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    Preferred Names
    Erg29p
    NP_013853.1
    • hypothetical protein involved in ergosterol biosynthesis; conditional mutants produce less ergosterol, display impaired oxygen consumption, respiratory growth, mitochondrial iron utilization, and are more sensitive to oxidative stress; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; protein localizes to the cytoplasm, ER and nuclear envelope; highly conserved in ascomycetes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      537838..538551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182635.1 → NP_013853.1  TPA: Erg29p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZV7, P40207
      UniProtKB/TrEMBL
      A6ZMJ4, B5VPR2, C7GU84, C8ZEY9, N1NYU1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40207.1

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