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    SIP1 Sip1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852032, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SIP1
    Official Full Name
    Sip1p
    Primary source
    SGD:S000002830
    Locus tag
    YDR422C
    See related
    AllianceGenome:SGD:S000002830; FungiDB:YDR422C; VEuPathDB:YDR422C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to AMP-activated protein kinase activity. Involved in several processes, including positive regulation of pseudohyphal growth; protein phosphorylation; and regulation of protein-containing complex assembly. Located in cytosol; fungal-type vacuole; and vacuolar membrane. Part of nucleotide-activated protein kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SIP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1315326..1317773, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Hkr1p Neighboring gene Aro80p Neighboring gene Cad1p Neighboring gene dynein light chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclic AMP-dependent protein kinase regulates the subcellular localization of Snf1-Sip1 protein kinase. Hedbacker K, et al. Mol Cell Biol, 2004 Mar. PMID 14966266, Free PMC Article
    2. SIP1 is a catabolite repression-specific negative regulator of GAL gene expression. Mylin LM, et al. Genetics, 1994 Jul. PMID 8088514, Free PMC Article
    3. Genetic and carbon source regulation of phosphorylation of Sip1p, a Snf1p-associated protein involved in carbon response in Saccharomyces cerevisiae. Long RM, et al. Yeast, 1995 Mar. PMID 7785324
    4. The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis. Zhang J, et al. Mol Microbiol, 2010 Jul. PMID 20545859
    5. Beta-subunits of the SnRK1 complexes share a common ancestral function together with expression and function specificities; physical interaction with nitrate reductase specifically occurs via AKINbeta1-subunit. Polge C, et al. Plant Physiol, 2008 Nov. PMID 18768910, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mutant strain with only SIP1 expressed could utilize acetate, but neither ethanol nor glycerol.
      Title: The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to AMP-activated protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of protein-containing complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleotide-activated protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sip1p
    NP_010710.4
    • One of three alternate beta-subunits of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1315326..1317773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180730.3 → NP_010710.4  TPA: Sip1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010710.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT52, P32578
      UniProtKB/TrEMBL
      C7GTM9
      Conserved Domains (2) summary
      smart01010
      Location:687 → 804
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      cl28984
      Location:504 → 562
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32578.2

    Gene LinkOut

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