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    SPO20 Spo20p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855031, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPO20
    Official Full Name
    Spo20p
    Primary source
    SGD:S000004619
    Locus tag
    YMR017W
    See related
    AllianceGenome:SGD:S000004619; FungiDB:YMR017W; VEuPathDB:YMR017W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DBI9
    Summary
    Enables SNAP receptor activity; phosphatidic acid binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in ascospore-type prospore assembly. Located in nucleus; plasma membrane; and prospore membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Orthologous to human SNAP29 (synaptosome associated protein 29). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPO20 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (307489..308682)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene C-22 sterol desaturase Neighboring gene Sok2p Neighboring gene Pex9p Neighboring gene Stb4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positive and negative regulation of a SNARE protein by control of intracellular localization. Nakanishi H, et al. Mol Biol Cell, 2004 Apr. PMID 14742704, Free PMC Article
    2. Interaction of the Spo20 membrane-sensor motif with phosphatidic acid and other anionic lipids, and influence of the membrane environment. Horchani H, et al. PLoS One, 2014. PMID 25426975, Free PMC Article
    3. Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties. Putta P, et al. Biochim Biophys Acta, 2016 Nov. PMID 27480805
    4. Binding interactions control SNARE specificity in vivo. Yang HJ, et al. J Cell Biol, 2008 Dec 15. PMID 19064671, Free PMC Article
    5. Prospore membrane formation defines a developmentally regulated branch of the secretory pathway in yeast. Neiman AM. J Cell Biol, 1998 Jan 12. PMID 9425151, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of the Spo20 membrane-sensor motif with phosphatidic acid and other anionic lipids is secondary structure-specific.
      Title: Interaction of the Spo20 membrane-sensor motif with phosphatidic acid and other anionic lipids, and influence of the membrane environment.
    2. phosphatidic acid stimulates fusion catalyzed by the sporulation-specific t-SNARE light-chain Spo20p
      Title: In vitro fusion catalyzed by the sporulation-specific t-SNARE light-chain Spo20p is stimulated by phosphatidic acid.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore-type prospore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in prospore membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spo20p
    NP_013730.1
    • Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; binds to phosphatidic acid; SNAP-25 homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      307489..308682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182513.1 → NP_013730.1  TPA: Spo20p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013730.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZJ1, Q04359, Q6B245
      UniProtKB/TrEMBL
      C7GLA2, N1P059
      Conserved Domains (2) summary
      smart00397
      Location:327 → 392
      t_SNARE; Helical region found in SNAREs
      cd15886
      Location:176 → 245
      SNARE_SEC9N; N-terminal SNARE motif of SEC9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04359.1

    Gene LinkOut

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