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    MTC5 Mtc5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851706, updated on 29-Jun-2024

    Summary

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    Gene symbol
    MTC5
    Gene description
    Mtc5p
    Primary source
    FungiDB:YDR128W
    Locus tag
    YDR128W
    See related
    SGD:S000002535; AllianceGenome:SGD:S000002535; VEuPathDB:YDR128W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEA3
    Summary
    Involved in positive regulation of TORC1 signaling. Is extrinsic component of fungal-type vacuolar membrane. Part of Seh1-associated complex. Orthologous to human WDR59 (WD repeat domain 59). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MTC5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (709549..712995)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene palmitoyltransferase SWF1 Neighboring gene pentafunctional protein ARO1p Neighboring gene fimbrin Neighboring gene Fin1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae. Polleys EJ, et al. G3 (Bethesda), 2015 May 4. PMID 25943524, Free PMC Article
    2. Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Panchaud N, et al. Sci Signal, 2013 May 28. PMID 23716719
    3. Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis. Ajazi A, et al. Dev Cell, 2021 Sep 27. PMID 34534458
    4. A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Dokudovskaya S, et al. Mol Cell Proteomics, 2011 Jun. PMID 21454883, Free PMC Article
    5. Molecular architecture and function of the SEA complex, a modulator of the TORC1 pathway. Algret R, et al. Mol Cell Proteomics, 2014 Nov. PMID 25073740, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The sea3 mutants exhibited a delay in colony formation in a BIR assay strain after double-strand break (DSB) induction as well as on the DNA-damaging agent bleomycin.
      Title: Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Seh1-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Seh1-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mtc5p
    NP_010413.3
    • Subunit of SEACAT, a subcomplex of the SEA complex; Mtc1p, along with Rtc1p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; relative distribution to the vacuolar membrane decreases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      709549..712995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180436.3 → NP_010413.3  TPA: Mtc5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010413.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSB4, Q03897
      UniProtKB/TrEMBL
      A0A8H8UN42, B5VG26
      Conserved Domains (5) summary
      PLN00181
      Location:143 → 346
      PLN00181; protein SPA1-RELATED; Provisional
      smart00591
      Location:433 → 543
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      sd00039
      Location:29 → 63
      7WD40; WD40 repeat [structural motif]
      pfam17120
      Location:1092 → 1147
      Zn_ribbon_17; Zinc-ribbon, C4HC2 type
      cl29593
      Location:70 → 230
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03897.1

    Gene LinkOut

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