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    SDS3 Sds3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854725, updated on 17-May-2024

    Summary

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    Gene symbol
    SDS3
    Gene description
    Sds3p
    Primary source
    FungiDB:YIL084C
    Locus tag
    YIL084C
    See related
    SGD:S000001346; AllianceGenome:SGD:S000001346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to histone deacetylase activity. Involved in several processes, including cell adhesion involved in single-species biofilm formation; regulation of gene expression; and regulation of invasive growth in response to glucose limitation. Located in cytosol and nucleus. Part of Rpd3L complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SDS3 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (202276..203259, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative mannosyltransferase Neighboring gene phosphopantothenate--cysteine ligase CAB2 Neighboring gene gag-pol fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity. Lechner T, et al. J Biol Chem, 2000 Dec 29. PMID 11024051
    2. Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. Searle NE, et al. Genetics, 2017 Mar. PMID 28108589, Free PMC Article
    3. Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. Vannier D, et al. Genetics, 1996 Dec. PMID 8978024, Free PMC Article
    4. NuA4 acetyltransferase is required for efficient nucleotide excision repair in yeast. Hodges AJ, et al. DNA Repair (Amst), 2019 Jan. PMID 30473425, Free PMC Article
    5. The roles of the catalytic and noncatalytic activities of Rpd3L and Rpd3S in the regulation of gene transcription in yeast. Yeheskely-Hayon D, et al. PLoS One, 2013. PMID 24358376, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L complex HDA PubMed 
    part_of Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L-Expanded complex HDA PubMed 
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sds3p
    NP_012182.1
    • Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      202276..203259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179432.1 → NP_012182.1  TPA: Sds3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVK2, P40505
      UniProtKB/TrEMBL
      A0A8H4C1N1, G2WG67
      Conserved Domains (1) summary
      pfam08598
      Location:21 → 310
      Sds3; Sds3-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40505.1

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