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    dnf2 phospholipid-transporting ATPase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541560, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dnf2
    Official Full Name
    phospholipid-transporting ATPase
    Primary source
    PomBase:SPAC24B11.12c
    Locus tag
    SPOM_SPAC24B11.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See dnf2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (224080..229236, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene chitin synthase regulatory factor-like Chr3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase (NDR family) Sid2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene hydroxymethylbilane synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs. Roland BP, et al. J Biol Chem, 2019 Feb 8. PMID 30530492, Free PMC Article
    2. The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. Fontebasso Y, et al. DNA Repair (Amst), 2013 Dec. PMID 24192486, Free PMC Article
    3. The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. Calvo IA, et al. iScience, 2021 Nov 19. PMID 34805795, Free PMC Article
    4. Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Telekawa C, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321377, Free PMC Article
    5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosylceramide flippase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylcholine floppase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine flippase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylserine floppase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycolipid translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum HDA PubMed 
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      224080..229236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018250.3 → NP_592849.1  phospholipid-transporting ATPase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592849.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09891, Q9USC3
      Conserved Domains (5) summary
      COG4087
      Location:989 → 1045
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01652
      Location:85 → 1295
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:678 → 773
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:85 → 129
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1038 → 1287
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    Nucleotide Protein
    Heading Accession and Version

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