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    MDM34 ERMES complex subunit MDM34 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852654, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MDM34
    Official Full Name
    ERMES complex subunit MDM34
    Primary source
    SGD:S000003187
    Locus tag
    YGL219C
    See related
    AllianceGenome:SGD:S000003187; FungiDB:YGL219C; VEuPathDB:YGL219C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MMM2
    Summary
    Predicted to enable lipid binding activity. Involved in mitochondrion organization; mitochondrion-endoplasmic reticulum membrane tethering; and phospholipid transport. Located in mitochondrial outer membrane. Part of ERMES complex. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MDM34 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (82878..84257, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bol2p Neighboring gene tubulin-dependent ATPase KIP3 Neighboring gene Clg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A proteomic screen reveals the mitochondrial outer membrane protein Mdm34p as an essential target of the F-box protein Mdm30p. Ota K, et al. Genes Cells, 2008 Oct. PMID 18775025
    2. Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids. Youngman MJ, et al. J Cell Biol, 2004 Mar 1. PMID 14981098, Free PMC Article
    3. Improved Split-GFP Systems for Visualizing Organelle Contact Sites in Yeast and Human Cells. Tashiro S, et al. Front Cell Dev Biol, 2020. PMID 33330450, Free PMC Article
    4. Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy. Belgareh-Touzé N, et al. Autophagy, 2017 Jan 2. PMID 27846375, Free PMC Article
    5. Contacts in Death: The Role of the ER-Mitochondria Axis in Acetic Acid-Induced Apoptosis in Yeast. Martins VM, et al. J Mol Biol, 2019 Jan 18. PMID 30414966

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mdm34 and Mdm12, 2 components of the endoplasmic reticulum-mitochondrial encounter structure, are ubiquitinated by the E3 ligase Rsp5
      Title: Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy.
    2. Pex11 and Mdm34 physically interact.
      Title: Genome-Wide Localization Study of Yeast Pex11 Identifies Peroxisome-Mitochondria Interactions through the ERMES Complex.
    3. These results indicate that Mdm34p is a physiologically important target of Mdm30p.
      Title: A proteomic screen reveals the mitochondrial outer membrane protein Mdm34p as an essential target of the F-box protein Mdm30p.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ERMES complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ERMES complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ERMES complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ERMES complex subunit MDM34
    NP_011296.1
    • Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      82878..84257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181084.1 → NP_011296.1  TPA: ERMES complex subunit MDM34 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011296.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZTX2, B5VIB8, D6VTT9, P53083
      UniProtKB/TrEMBL
      C7GWY1, C8Z836, N1P9Y4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53083.1

    Gene LinkOut

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