HOP1 Hop1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HOP1
Official Full Name: Hop1p
Primary source: SGD:S000001334
Locus tag: YIL072W
See related: AllianceGenome:SGD:S000001334; FungiDB:YIL072W; VEuPathDB:YIL072W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables chromatin binding activity and four-way junction DNA binding activity. Involved in activation of reciprocal meiotic recombination; meiotic recombination checkpoint signaling; and synaptonemal complex assembly. Located in lateral element. Orthologous to several human genes including HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See HOP1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (226602..228419)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Turning coldspots into hotspots: targeted recruitment of axis protein Hop1 stimulates meiotic recombination in Saccharomyces cerevisiae.
Title: Turning coldspots into hotspots: targeted recruitment of axis protein Hop1 stimulates meiotic recombination in Saccharomyces cerevisiae.
How do small chromosomes know they are small? Maximizing meiotic break formation on the shortest yeast chromosomes.
Title: How do small chromosomes know they are small? Maximizing meiotic break formation on the shortest yeast chromosomes.
Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1.
Title: Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1.
Data show that Hop1 protein possesses conformational dynamics similar to spindle checkpoint protein MAD2 (Mad2), and identify closure motifs in the Hop1 binding partner Red1 protein.
Title: Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2.
crystal structures of the Mek1 FHA domain in the apo state and in complex with the Hop1 pT318 peptide are presented, demonstrating that the hydrophobic residues Phe320 and Val321 at the pT+2 and pT+3 positions in the ligand contribute to the preferential recognition.
Title: Structural insights into the recognition of phosphorylated Hop1 by Mek1.
These localization patterns closely tracked the distribution of Red1 and Hop1, axis proteins required for Mek1 activation. These findings provide insight into the spatial disposition of Mek1 kinase activity and the higher order organization of recombining meiotic chromosomes
Title: Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.
Hop1 phospho-T318 and phospho-S298 constitute key components of the Tel1/Mec1- based meiotic recombination surveillance (MRS) network and facilitate coupling of meiotic recombination and progression during both unperturbed and challenged meiosis
Title: Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1.
Pch2 prevents Mec1/Tel1-mediated Hop1 phosphorylation occurring independently of Red1 in Saccharomyces cerevisiae meiosis.
Title: Pch2 prevents Mec1/Tel1-mediated Hop1 phosphorylation occurring independently of Red1 in budding yeast meiosis.
Pch2 displaces Hop1 from large DNA substrates and both ATP binding and hydrolysis by Pch2 are required for Pch2-Hop1 transactions
Title: Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1.
N-terminal domain of Hop1 protein is dispensable for DNA binding, bridging, and synapsis of double-stranded DNA molecules but is necessary for spore formation.
Title: N-terminal disordered domain of Saccharomyces cerevisiae Hop1 protein is dispensable for DNA binding, bridging, and synapsis of double-stranded DNA molecules but is necessary for spore formation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables four-way junction DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables four-way junction DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome pairing at meiosis	IEA Inferred from Electronic Annotation more info
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic recombination checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic recombination checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in meiotic recombination checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptonemal complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptonemal complex assembly	IEA Inferred from Electronic Annotation more info
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hop1p

NP_012193.3

Meiosis-specific HORMAD protein required for chromosome synapsis; displays Red1p-dependent localization to unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; binds chromatin to regulate initiation of meiotic recombination; promotes intra- and intermolecular synapsis between dsDNA molecules and folds DNA into rigid protein-DNA filaments in vitro; contains a HORMA domain, and a chromatin-binding region made up of PHD and winged helix-turn-helix domains