MED11 Med11p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MED11
Official Full Name: Med11p
Primary source: SGD:S000004718
Locus tag: YMR112C
See related: AllianceGenome:SGD:S000004718; FungiDB:YMR112C; VEuPathDB:YMR112C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables TFIIH-class transcription factor complex binding activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables TFIIH-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of core mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_013830.1

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein

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