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    HMLALPHA1 transcriptional co-activator mating type protein alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850293, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HMLALPHA1
    Official Full Name
    transcriptional co-activator mating type protein alpha
    Primary source
    SGD:S000000571
    Locus tag
    YCL066W
    See related
    AllianceGenome:SGD:S000000571; FungiDB:YCL066W; VEuPathDB:YCL066W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ALPHA1
    Summary
    Predicted to enable DNA binding activity, bending and transcription coactivator activity. Predicted to be involved in regulation of mating-type specific transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HMLALPHA1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (13282..13809)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene homeodomain mating type protein alpha2 Neighboring gene L-serine/L-threonine ammonia-lyase CHA1 Neighboring gene Vac17p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris. Bader O, et al. BMC Microbiol, 2008 Jul 14. PMID 18625069, Free PMC Article
    2. Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins. Yuan YO, et al. Genes Dev, 1993 Aug. PMID 8339934
    3. DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Tan S, et al. Cell, 1990 Jul 27. PMID 2164891
    4. MAT alpha 1 can mediate gene activation by a-mating factor. Sengupta P, et al. Genes Dev, 1991 Oct. PMID 1916267
    5. Lack of a requirement for strict rotational alignment among transcription factor binding sites in yeast. Inokuchi K, et al. Nucleic Acids Res, 1991 Jun 11. PMID 1905400, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables transcription coactivator activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of mating-type specific transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mating-type specific transcription, DNA-templated ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional co-activator mating type protein alpha
    NP_009867.1
    • Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      13282..13809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178707.1 → NP_009867.1  TPA: transcriptional co-activator mating type protein alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009867.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQV3, P01365, P0CY06, P0CY07
      UniProtKB/TrEMBL
      A6ZTM2, B3LU21, C8Z425, G2WA58
      Conserved Domains (1) summary
      pfam04769
      Location:84 → 143
      MATalpha_HMGbox; Mating-type protein MAT alpha 1 HMG-box
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CY06.1
    P0CY07.1

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