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    sfr1 DNA recombination mediator Sfr1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540584, updated on 14-Nov-2024

    Summary

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    Official Symbol
    sfr1
    Official Full Name
    DNA recombination mediator Sfr1
    Primary source
    PomBase:SPBC28F2.07
    Locus tag
    SPOM_SPBC28F2.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    dds20; mug13
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    Genomic context

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    See sfr1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1580456..1581880)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene xylose and arabinose reductase Neighboring gene ncRNA Neighboring gene Prp19 complex subunit Cwf7 Neighboring gene ERMES complex subunit, membrane tether and lipid transfer protein Mdm12 Neighboring gene HRD ubiquitin ligase complex subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor TFIIA complex large subunit Toa1 Neighboring gene SAGA complex subunit Ngg1/Ada3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [New Class of Sfr1 Protein Repeats Essential for Homologous Recombination in Schizosaccharomyces pombe Yeast in Mitosis]. Khasanova OS, et al. Mol Biol (Mosk), 2016 Jan-Feb. PMID 27028824
    2. CDK phosphorylation of Sfr1 downregulates Rad51 function in late-meiotic homolog invasions. Palacios-Blanco I, et al. EMBO J, 2024 Oct. PMID 39174851, Free PMC Article
    3. Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1. Liang P, et al. J Biol Chem, 2023 Aug. PMID 37330173, Free PMC Article
    4. Mapping and Analysis of Swi5 and Sfr1 Phosphorylation Sites. Sevcovicova A, et al. Genes (Basel), 2021 Jun 30. PMID 34208949, Free PMC Article
    5. Characterisation of an intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering. Saikusa K, et al. Analyst, 2013 Mar 7. PMID 23324799

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1.
      Title: Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1.
    2. Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1 filament assembly using distinct mechanisms.
      Title: Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1 filament assembly using distinct mechanisms.
    3. new class of Sfr1 tandem protein repeats essential for homologous recombination in Schizosaccharomyces pombe mitosis
      Title: [New Class of Sfr1 Protein Repeats Essential for Homologous Recombination in Schizosaccharomyces pombe Yeast in Mitosis].
    4. Authors propose that the role of a coplanar alignment of nucleobases induced by Swi5-Sfr1 in the presynaptic Rad51/ssDNA complex is to facilitate the critical matching with an invading double-stranded DNA, hence stimulating the strand exchange reaction.
      Title: Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament.
    5. Characterized is the intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering.
      Title: Characterisation of an intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering.
    6. Data propose a model for how the Swi5-Sfr1 complex binds to the Rad51 filament, in which the Swi5-Sfr1 complex fits into the groove of the Rad51 filament, leading to an active and stable presynaptic filament.
      Title: Fission yeast Swi5-Sfr1 protein complex, an activator of Rad51 recombinase, forms an extremely elongated dogleg-shaped structure.
    7. Sfr1 acts early in recombination and has a specific role in Rad51 filament assembly, distinct from that of the Rad51 paralogs
      Title: Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair.
    8. Schizosaccharomyces pombe Swi5-Sfr1 complex, a conserved eukaryotic protein complex, at substoichiometric concentrations stimulates strand exchange mediated by Rhp51 (the S. pombe Rad51 homolog) and Dmc1 on long DNA substrates.
      Title: The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA strand invasion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair involved in meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in mating type switching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA recombinase assembly involved in reciprocal meiotic recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic joint molecule formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic strand invasion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Swi5-Sfr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swi5-Sfr1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA recombination mediator Sfr1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1580456..1581880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021563.3 → NP_595668.1  DNA recombination mediator Sfr1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595668.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78932, Q9USV1
      Conserved Domains (1) summary
      pfam10376
      Location:71 → 291
      Mei5; Double-strand recombination repair protein
    Nucleotide Protein
    Heading Accession and Version

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