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    RPE1 ribulose-phosphate 3-epimerase RPE1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853322, updated on 9-Jun-2024

    Summary

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    Gene symbol
    RPE1
    Gene description
    ribulose-phosphate 3-epimerase RPE1
    Primary source
    FungiDB:YJL121C
    Locus tag
    YJL121C
    See related
    SGD:S000003657; AllianceGenome:SGD:S000003657; VEuPathDB:YJL121C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EPI1; POS18
    Summary
    Enables ribulose-phosphate 3-epimerase activity. Involved in pentose-phosphate shunt. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to several human genes including RPE (ribulose-5-phosphate-3-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPE1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (190374..191090, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mtc1p Neighboring gene Alb1p Neighboring gene uncharacterized protein Neighboring gene Pho86p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iterative optimization of xylose catabolism in Saccharomyces cerevisiae using combinatorial expression tuning. Latimer LN, et al. Biotechnol Bioeng, 2017 Jun. PMID 28165133
    2. Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional (13)C labeling of common amino acids. Maaheimo H, et al. Eur J Biochem, 2001 Apr. PMID 11298766
    3. Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Miosga T, et al. Curr Genet, 1996 Nov. PMID 8929392
    4. Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae. Gorsich SW, et al. Appl Microbiol Biotechnol, 2006 Jul. PMID 16222531
    5. Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress. Juhnke H, et al. Mol Gen Genet, 1996 Sep 25. PMID 8879247

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-ribulose-phosphate 3-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-ribulose-phosphate 3-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-ribulose-phosphate 3-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-ribulose-phosphate 3-epimerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribulose-phosphate 3-epimerase RPE1
    NP_012414.1
    • D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      190374..191090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181554.1 → NP_012414.1  TPA: ribulose-phosphate 3-epimerase RPE1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW65, P46969
      UniProtKB/TrEMBL
      A0A6A5PTK5, A6ZQL0, B3LPZ8, C7GQ07, C8ZB98, G2WGQ2, N1P417
      Conserved Domains (1) summary
      PTZ00170
      Location:3 → 234
      PTZ00170; D-ribulose-5-phosphate 3-epimerase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46969.1

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