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    prw1 histone chaperone, Clr6 and Rpd3L complex subunit Prw1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541804, updated on 18-Sep-2024

    Summary

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    Official Symbol
    prw1
    Official Full Name
    histone chaperone, Clr6 and Rpd3L complex subunit Prw1
    Primary source
    PomBase:SPAC29A4.18
    Locus tag
    SPOM_SPAC29A4.18
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See prw1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (5110278..5111882, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene Ca(2+)/Mn(2+)-transporting P-type ATPase P5 type Cta5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene integral mitochondrial outer membrane (MOM) protein Neighboring gene serine/threonine protein kinase Hal4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the Neural REST/NRSF-SIN3 Transcriptional Corepressor Complex as a Target for Small-Molecule Inhibitors. Jayaprakash S, et al. Mol Biotechnol, 2021 Jan. PMID 33130996
    2. Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity. Nakayama J, et al. EMBO J, 2003 Jun 2. PMID 12773392, Free PMC Article
    3. Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection. Nicolas E, et al. Nat Struct Mol Biol, 2007 May. PMID 17450151
    4. Two assembly modes for SIN3 histone deacetylase complexes. Wang C, et al. Cell Discov, 2023 Apr 19. PMID 37076472, Free PMC Article
    5. Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase. Kaufmann I, et al. Mol Cell Biol, 2010 Jul. PMID 20404084, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables H3-H4 histone complex chaperone activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3L-Expanded complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3S complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    NOT is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone chaperone, Clr6 and Rpd3L complex subunit Prw1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5110278..5111882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020293.3 → NP_594864.1  histone chaperone, Clr6 and Rpd3L complex subunit Prw1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594864.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14021
      Conserved Domains (4) summary
      COG2319
      Location:99 → 410
      WD40; WD40 repeat [General function prediction only]
      pfam12265
      Location:28 → 96
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      sd00039
      Location:133 → 182
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:110 → 410
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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