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    TMA46 Tma46p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854258, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMA46
    Official Full Name
    Tma46p
    Primary source
    SGD:S000005617
    Locus tag
    YOR091W
    See related
    AllianceGenome:SGD:S000005617; FungiDB:YOR091W; VEuPathDB:YOR091W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in cytoplasmic translation. Located in cytoplasm. Orthologous to human ZC3H15 (zinc finger CCCH-type containing 15). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TMA46 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (493433..494470)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rab family GTPase VPS21 Neighboring gene type 2C protein phosphatase PTC5 Neighboring gene putative ATPase ECM3 Neighboring gene Cmr2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rbg1-Tma46 dimer structure reveals new functional domains and their role in polysome recruitment. Francis SM, et al. Nucleic Acids Res, 2012 Nov. PMID 23002146, Free PMC Article
    2. Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation. Ishikawa K, et al. Genes Cells, 2013 Oct. PMID 23899355
    3. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Zeng F, et al. Cell Rep, 2021 Oct 26. PMID 34706231, Free PMC Article
    4. Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Wout PK, et al. Eukaryot Cell, 2009 Jul. PMID 19448108, Free PMC Article
    5. The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1. Daugeron MC, et al. Nucleic Acids Res, 2011 Mar. PMID 21076151, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells.
      Title: Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tma46p
    NP_014734.2
    • hypothetical protein that associates with translating ribosomes; interacts with GTPase Rbg1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      493433..494470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183510.1 → NP_014734.2  TPA: Tma46p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014734.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2F2, Q12000
      UniProtKB/TrEMBL
      B3LJD7, B5VRY7, C7GMP3, C8ZI52, G2WMW8, N1NYD0
      Conserved Domains (1) summary
      COG5252
      Location:1 → 336
      COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12000.2

    Gene LinkOut

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